ArticleMolecular and cellular biology1995
Gene conversion as a secondary mechanism of short interspersed element (SINE) evolution.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 113 citations in OpenAlex.
- Analysis of SINE Families B2, Dip, and Ves with Special Reference to Polyadenylation Signals and Transcription Terminators.International journal of molecular sciences · 2021Article
- Gene Conversion amongstGenes · 2021Article
- Long-read assembly of a Great Dane genome highlights the contribution of GC-rich sequence and mobile elements to canine genomes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- What Can Long Terminal Repeats Tell Us About the Age of LTR Retrotransposons, Gene Conversion and Ectopic Recombination?Frontiers in plant science · 2020Article
- Structural variation and its potential impact on genome instability: Novel discoveries in the EGFR landscape by long-read sequencing.PloS one · 2020Article
- The Role of Gene Conversion between Transposable Elements in Rewiring Regulatory Networks.Genome biology and evolution · 2019Review
- Review
- Discovery of a new repeat family in the Callithrix jacchus genome.Genome research · 2016Article
- A Novel Terminal-Repeat Retrotransposon in Miniature (TRIM) Is Massively Expressed in Echinococcus multilocularis Stem Cells.Genome biology and evolution · 2015Article
- Article
- Diverse mutational mechanisms cause pathogenic subtelomeric rearrangements.Human molecular genetics · 2011Article
- LINEs and SINEs of primate evolution.Evolutionary anthropology · 2010Article
- Recombination-associated sequence homogenization of neighboring Alu elements: signature of nonallelic gene conversion.Molecular biology and evolution · 2010Article
- The impact of retrotransposons on human genome evolution.Nature reviews. Genetics · 2009Review
- Article
- An alternative pathway for Alu retrotransposition suggests a role in DNA double-strand break repair.Genomics · 2009Article
- On the evolution and expression of Chlamydomonas reinhardtii nucleus-encoded transfer RNA genes.Genetics · 2008Article
- Analysis of the features and source gene composition of the AluYg6 subfamily of human retrotransposons.BMC evolutionary biology · 2007Article
- Recent integrations of mammalian Hmg retropseudogenes.Journal of genetics · 2006Article
- Human endogenous retroviral elements as indicators of ectopic recombination events in the primate genome.Genetics · 2005Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The Alu repetitive family of short interspersed elements (SINEs) in primates can be subdivided into distinct subfamilies by specific diagnostic nucleotide changes. The older subfamilies are generally very abundant, while the younger subfamilies have fewer copies. Some of the youngest Alu elements are absent in the orthologous loci of nonhuman primates, indicative of recent retroposition events, the primary mode of SINE evolution. PCR analysis of one young Alu subfamily (Sb2) member found in the low-density lipoprotein receptor gene apparently revealed the presence of this element in the green monkey, orangutan, gorilla, and chimpanzee genomes, as well as the human genome. However, sequence analysis of these genomes revealed a highly mutated, older, primate-specific Alu element was present at this position in the nonhuman primates. Comparison of the flanking DNA sequences upstream of this Alu insertion corresponded to evolution expected for standard primate phylogeny, but comparison of the Alu repeat sequences revealed that the human element departed from this phylogeny. The change in the human sequence apparently occurred by a gene conversion event only within the Alu element itself, converting it from one of the oldest to one of the youngest Alu subfamilies. Although gene conversions of Alu elements are clearly very rare, this finding shows that such events can occur and contribute to specific cases of SINE subfamily evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.