ArticleMolecular and cellular biology1995
Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
97 citing papers in PubMed, 455 citations in OpenAlex.
- Activin A-Targeted Therapy in Cancer: An Updated Review on Challenges and Opportunities in Clinical Translation.Current pharmaceutical design · 2026Review
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- The negative regulation of gene expression by microRNAs as key driver of inducers and repressors of cardiomyocyte differentiation.Clinical science (London, England : 1979) · 2022Review
- Cpmer: A new conserved eEF1A2-binding partner that regulates Eomes translation and cardiomyocyte differentiation.Stem cell reports · 2022Article
- Generation of Human Induced Pluripotent Stem Cells and Differentiation into Cardiomyocytes.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Cellular Plasticity in Musculoskeletal Development, Regeneration, and Disease.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Review
- Loss of Myeloid BMPR1a Alters Differentiation and Reduces Mouse Prostate Cancer Growth.Frontiers in oncology · 2020Article
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- Allele-specific RNA-seq expression profiling of imprinted genes in mouse isogenic pluripotent states.Epigenetics & chromatin · 2019Article
- An iPSC-Derived Myeloid Lineage Model of Herpes Virus Latency and Reactivation.Frontiers in microbiology · 2019Article
- Markers associated with neuron-specific Ube3a imprinting during neuronal differentiation of mouse embryonic stem cells.Cytotechnology · 2018Article
- It Takes Two: Endothelial-Perivascular Cell Cross-Talk in Vascular Development and Disease.Frontiers in cardiovascular medicine · 2018Review
- The many faces of Pluripotency: in vitro adaptations of a continuum of in vivo states.BMC developmental biology · 2017Review
- Hepatocyte-like cells derived from induced pluripotent stem cells.Hepatology international · 2017Review
- Comparison of two types of non-adherent plate for neuronal differentiation of mouse embryonic stem cells.Cytotechnology · 2016Article
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- Pluripotency Factors on Their Lineage Move.Stem cells international · 2016Review
- Collaborative rewiring of the pluripotency network by chromatin and signalling modulating pathways.Nature communications · 2015Article
- Tissue-engineered vascular grafts created from human induced pluripotent stem cells.Stem cells translational medicine · 2014Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Xenopus in vitro studies have implicated both transforming growth factor beta (TGF-beta) and fibroblast growth factor (FGF) families in mesoderm induction. Although members of both families are present during mouse mesoderm formation, there is little evidence for their functional role in mesoderm induction. We show that mouse embryonic stem cells, which resemble primitive ectoderm, can differentiate to mesoderm in vitro in a chemically defined medium (CDM) in the absence of fetal bovine serum. In CDM, this differentiation is responsive to TGF-beta family members in a concentration-dependent manner, with activin A mediating the formation of dorsoanterior-like mesoderm and bone morphogenetic protein 4 mediating the formation of ventral mesoderm, including hematopoietic precursors. These effects are not observed in CDM alone or when TGF-beta 1, -beta 2, or -beta 3, acid FGF, or basic FGF is added individually to CDM. In vivo, at day 6.5 of mouse development, activin beta A RNA is detectable in the decidua and bone morphogenetic protein 4 RNA is detectable in the egg cylinder. Together, our data strongly implicate the TGF-beta family in mammalian mesoderm development and hematopoietic cell formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.