ArticleThe Journal of cell biology1994
Facilitated nuclear transport of calmodulin in tissue culture cells.
Article in The Journal of cell biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 67 citations in OpenAlex.
- Calcium and Nuclear Signaling in Prostate Cancer.International journal of molecular sciences · 2018Review
- Stimulation-mediated translocation of calmodulin and neurogranin from soma to dendrites of mouse hippocampal CA1 pyramidal neurons.Neuroscience · 2011Article
- Transportin mediates nuclear entry of DNA in vertebrate systems.Traffic (Copenhagen, Denmark) · 2009Article
- Calmodulin-driven nuclear entry: trigger for sex determination and terminal differentiation.The Journal of biological chemistry · 2009Review
- Significance of nuclear glutathione S-transferase pi in resistance to anti-cancer drugs.Japanese journal of cancer research : Gann · 2002Article
- Model system to study classical nuclear export signals.AAPS pharmSci · 2002Article
- Calmodulin priming: nuclear translocation of a calmodulin complex and the memory of prior neuronal activity.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Yeast nucleoporins involved in passive nuclear envelope permeability.The Journal of cell biology · 2000Article
- An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B" spliceosome proteins.The Journal of cell biology · 2000Article
- Nucleocytoplasmic shuttling: a novel in vivo property of antisense phosphorothioate oligodeoxynucleotides.Nucleic acids research · 2000Article
- Critical dependence of cAMP response element-binding protein phosphorylation on L-type calcium channels supports a selective response to EPSPs in preference to action potentials.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Mechanism of Ca2+-dependent nuclear accumulation of calmodulin.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Hormone-induced secretory and nuclear translocation of calmodulin: oscillations of calmodulin concentration with the nucleus as an integrator.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Ran-unassisted nuclear migration of a 97-kD component of nuclear pore-targeting complex.The Journal of cell biology · 1997Article
- The role of the nuclear pore complex in adenovirus DNA entry.The EMBO journal · 1997Article
- Calmodulin activates nuclear protein import: a link between signal transduction and nuclear transport.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- In vivo nuclear transport kinetics in Saccharomyces cerevisiae: a role for heat shock protein 70 during targeting and translocation.The Journal of cell biology · 1996Article
- Nuclear import in permeabilized protoplasts from higher plants has unique features.The Plant cell · 1996Article
- Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimera.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Calmodulin (CaM) potentiates Ca(2+)-dependent signaling pathways in both the cytoplasm and nucleus. We have investigated the mechanism of CaM nuclear transport using tissue culture cell microinjection and a permeabilized cell import assay. The inhibition of CaM import by the translocation inhibitor wheat germ agglutinin (WGA) and by chilling, indicates that CaM import is facilitated, but because ATP depletion does not affect CaM import, the mechanism does not appear to be active. Chilling and WGA arrest persist in ATP-depleted cells, indicating that CaM is not retained in the cytoplasm by an ATP-dependent mechanism. In permeabilized cells, both Ca(2+)-CaM and Ca(2+)-free CaM are sensitive to extract-dependent WGA and chilling import inhibition. Titration experiments in microinjected and permeabilized cells indicate that a saturable cytosolic factor(s) mediates chilling and WGA arrest.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.