ArticleJournal of cancer research and clinical oncology1995
Bcl-2 expression and its association with cell kinetics in human gastric carcinomas and intestinal metaplasia.
Article in Journal of cancer research and clinical oncology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Bcl-2 expression and patient survival in gastric cancer: a systematic review of the literature with meta-analysis.Medical oncology (Northwood, London, England) · 2015Pooled it
- Functions of the AP-2α gene in activating apoptosis and inhibiting proliferation of gastric cancer cells bothArchives of medical science : AMS · 2017Article
- Regulation of apoptosis is impaired in atrophic gastritis associated with gastric cancer.BMC gastroenterology · 2017Article
- Prediction of tumor recurrence after curative resection in gastric carcinoma based on bcl-2 expression.World journal of surgical oncology · 2014Article
- Depressed type of intramucosal differentiated-type gastric cancer has high cell proliferation and reduced apoptosis compared with the elevated type.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2013Article
- Impact of biomarkers expression before and after portal vein embolization on recurrence after two-stage hepatectomy for colorectal liver metastases.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2012Article
- The prognostic significance of apoptosis-related biological markers in Chinese gastric cancer patients.PloS one · 2011Article
- Prognostic significance of Bcl-2 and p53 expression in gastric cancer.International journal of colorectal disease · 2003Article
- Potential role of bcl-2 and ki-67 expression and apoptosis in colorectal carcinoma: a clinicopathologic study.Digestive diseases and sciences · 2003Article
- Diffuse and intestinal type gastric carcinomas differ in their expression of apoptosis related proteins.Journal of clinical pathology · 2003Article
- Increased apoptosis associated with depressed type of early intestinal gastric cancer.Japanese journal of cancer research : Gann · 2001Article
- Transretinoic acid inhibits rats gastric epithelial dysplasia induced by N-methyl-N-nitro-N-nitrosoguanidine: influences on cell apoptosis and expression of its regulatory genes.World journal of gastroenterology · 2001Article
- Characterization and isolation of ductular cells coexpressing neural cell adhesion molecule and Bcl-2 from primary cholangiopathies and ductal plate malformations.The American journal of pathology · 2000Article
- Bcl-2 and p53 protein expression, apoptosis, and p53 mutation in human epithelial ovarian cancers.The American journal of pathology · 2000Article
- Review
- Bcl-2 is closely correlated with favorable prognostic factors and inversely associated with p53 protein accumulation in endometrial carcinomas: immunohistochemical and polymerase chain reaction/loss of heterozygosity findings.Journal of cancer research and clinical oncology · 1997Article
- Apoptosis, cell proliferation and expression of Bcl-2 and Bax in gastric carcinomas: immunohistochemical and clinicopathological study.British journal of cancer · 1997Article
- Bcl-2 expression and allelic loss of the p53 gene in gastric carcinomas.Journal of cancer research and clinical oncology · 1996Article
- Apoptosis of colon cancer: comparison with Ki-67 proliferative activity and expression of p53.Journal of cancer research and clinical oncology · 1996Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bcl-2 protooncogene was initially discovered at the t(14;18) chromosomal breakpoint in follicular lymphomas. It has been demonstrated that bcl-2 protein (Bcl-2) expression blocks apoptosis and plays an important role in cell development and maturation. In the present study, Bcl-2 expression was immunohistochemically examined in 103 cases of gastric carcinoma, as well as 64 cases of non-carcinous gastric mucosa, and its correlation with apoptosis, cell proliferation and p53 immunoreactivity was investigated. Bcl-2 was detected in 18.0% of differentiated-type gastric carcinomas (9 of 50) and 7.5% of the undifferentiated type (4 of 53). In adjacent intestinal metaplastic gastric epithelium, the incidence of Bcl-2 positivity in the incomplete type (21/23, 91.3%) was significantly higher than in the complete type (23/41, 56.1%) (P < 0.04). Double immunostaining for Bcl-2 and Ki-67 clearly revealed the majority of Bcl-2-positive cancer cells to be in a nonproliferating state, although some cancer cells expressed both proteins together. Statistical assessment demonstrated that the average Ki-67 labeling index and apoptotic labeling index in Bcl-2-positive foci were significantly lower than in Bcl-2-negative foci (P < 0.0001, P < 0.0003). In addition, a significant dissociation between Bcl-2 and p53 immunoreactivity was found in cancer tissues. These results indicate that aberrant Bcl-2 expression in gastric carcinomas possibly originates from intestinal metaplastic epithelium, and suggest a possible role in tumor development and growth.
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