ArticleDiabetologia1995
Insulin receptor substrate-1 gene mutations in NIDDM; implications for the study of polygenic disease.
Article in Diabetologia, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Gly972Arg variant in the insulin receptor substrate-1 gene and association with Type 2 diabetes: a meta-analysis of 27 studies.Diabetologia · 2003Pooled it
- Prevalence of Insulin Receptor Substrate-1 Gene (G972R) Polymorphism, Insulin Resistance, and Determination of β-Cell Function among Overweight and Obese Persons with Type 2 Diabetes Mellitus.Journal of the ASEAN Federation of Endocrine Societies · 2021Article
- Three Novel Mutations I65S, R66S, and G86R Divulge Significant Conformational Variations in the PTB Domain of the IRS1 Gene.ACS omega · 2019Article
- The role of insulin receptor substrate 1 gene polymorphism Gly972Arg as a risk factor for ischemic stroke among Indonesian subjects.BMC research notes · 2018Article
- IRS proteins and diabetic complications.Diabetologia · 2016Review
- Causal drift, robust signaling, and complex disease.PloS one · 2015Article
- Insulin receptor substrate 1 (IRS1) variants confer risk of diabetes in the Boston Puerto Rican Health Study.Asia Pacific journal of clinical nutrition · 2013Article
- Pathogenesis of insulin resistance in skeletal muscle.Journal of biomedicine & biotechnology · 2010 · on this mapReview
- No association of the IRS1 and PAX4 genes with type I diabetes.Genes and immunity · 2009Article
- Abnormal glucose tolerance and insulin resistance in polycystic ovary syndrome amongst the Taiwanese population- not correlated with insulin receptor substrate-1 Gly972Arg/Ala513Pro polymorphism.BMC medical genetics · 2006Article
- The G972R variant of the insulin receptor substrate-1 (IRS-1) gene is associated with insulin resistance in "uncomplicated" obese subjects evaluated by hyperinsulinemic-euglycemic clamp.Journal of endocrinological investigation · 2004Article
- Candidate genes for type 2 diabetes.Reviews in endocrine & metabolic disorders · 2004 · on this mapReview
- Genetics of insulin resistance.Current diabetes reports · 2002Review
- Insulin action in skeletal muscle from patients with NIDDM.Molecular and cellular biochemistry · 1998Review
- [1997 diabetes update].Medizinische Klinik (Munich, Germany : 1983) · 1997Review
- Pathophysiology of non-insulin-dependent diabetes and the search for candidate genes: dangerous liaisons?Acta diabetologica · 1996Review
- A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies.The Journal of clinical investigation · 1996Article
- Molecular scanning of the insulin receptor substrate-1 (IRS-1) gene in Japanese patients with NIDDM: identification of five novel polymorphisms.Diabetologia · 1996Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Variations in the coding regions of the insulin receptor substrate-1 (IRS-1) gene have recently been suggested to contribute to the susceptibility of non-insulin-dependent diabetes mellitus (NIDDM). The purpose of this study was to examine the role of the IRS-1 missense mutations at codons 972 (glycine to arginine) and 513 (alanine to proline) in two diverse populations from South India and Finland at high risk for NIDDM. DNA was amplified and digested with restriction enzymes BstN1 to detect the codon 972 mutation and Dra III to detect the codon 513 mutation. The codon 513 mutation was not found in the study subjects. The codon 972 mutation was present in 10.3% of 126 middle-aged NIDDM subjects and 5.3% of 95 matched control subjects in the South Indians (p = 0.17). In elderly Finnish subjects the frequency of the mutation was 7.5% in 40 NIDDM subjects and 7% in 42 matched control subjects. The frequency of codon 972 mutation in the South Indian NIDDM subjects was very similar to the two previously published studies in Danish and French subjects although each study individually fails to reach conventional levels of significance. The data from all four ethnic groups were analysed together after ascertaining that significant heterogeneity did not exist between the studies. Overall, the frequency of the codon 972 mutation is found in 10.7% NIDDM subjects and 5.8% control subjects (p = 0.02). These studies suggest that the codon 972 mutation of the IRS-1 gene might act as a susceptibility gene predisposing to NIDDM in certain ethnic groups.
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