Evidence map›Paper›PMID 7795447›Full record

ArticleBMJ (Clinical research ed.)1995

Reasons for non-uptake of measles, mumps, and rubella catch up immunisation in a measles epidemic and side effects of the vaccine.

R J Roberts, Q D Sandifer, M R Evans, M Z Nolan-Farrell, P M Davis

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in BMJ (Clinical research ed.), 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03460002 (A Cluster Randomized Controlled Trial on the Campaign Effect of Measles Vaccine and Oral Polio Vaccine on General Hospital Admissions and Mortality Among Children), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03460002 phase4completednot on this mapstarted 2016, after this paper: background citation

A Cluster Randomized Controlled Trial on the Campaign Effect of Measles Vaccine and Oral Polio Vaccine on General Hospital Admissions and Mortality Among Children

TypeinterventionalSponsorBandim Health ProjectRan2016 to 2022Enrolled28,612ConditionsMeasles Vaccination, Oral Polio Vaccine, Non-specific/Heterologous Effects of Vaccines, MortalityArmsMeasles vaccine, Oral polio vaccine
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  10. Imitation dynamics predict vaccinating behaviour.Proceedings. Biological sciences · 2005
    Article
  11. Vaccination and the theory of games.Proceedings of the National Academy of Sciences of the United States of America · 2004
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

R J RobertsPublic Health Laboratory, Service Communicable, Disease Surveillance Centre, Welsh Unit, Cardiff.
Q D Sandifer
M R Evans
M Z Nolan-Farrell
P M Davis
Welsh Government · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the reasons for poor uptake of immunisation (non-immunisation) and the possible side effects of measles, mumps, and rubella vaccine in a catch up immunisation campaign during a community outbreak of measles.

designDescriptive study of reasons for non-immunisation and retrospective cohort study of side effects of the vaccine.

settingSecondary schools in South Glamorgan. SUBJECTS: Random cluster sample of the parents of 500 children targeted but not immunised and a randomised sample of 2866 of the children targeted.

main outcome measuresReasons for non-immunisation; symptoms among immunised and non-immunised children.

resultsImmunisation coverage of the campaign was only 43.4% (7633/17,595). The practical problems experienced included non-return of consent forms (6698/17,595), refusal of immunisation (2061/10,897 forms returned), and absence from school on day of immunisation (1203/8836 children with consent for immunisation). The most common reasons cited for non-immunisation were previous measles infection (145/232), previous immunisation against measles (78/232), and concern about side effects (55/232). Symptoms were equally common among immunised and non-immunised subjects. However, significantly more immunised boys than non-immunised boys reported fever (relative risk 2.31 (95% confidence interval 1.36 to 3.93)), rash (2.00 (1.10 to 3.64), joint symptoms (1.58; 1.05 to 2.38), and headache (1.31 (1.04 to 1.65)).

conclusionsMany of the objections raised by parents could be overcome by emphasising that primary immunisation does not necessarily confer immunity and that diagnosis of measles is unreliable. Measles, mumps, and rubella vaccine is safe in children aged 11-15.

Indexed as

Measles VaccineMumps VaccineRubella VaccineAdolescentAttitude to HealthChildCohort StudiesDisease OutbreaksFemaleHumansImmunization, SecondaryMaleMeaslesMeasles-Mumps-Rubella VaccineParentsPatient Acceptance of Health CareMeasles-Mumps-Rubella VaccineMeasles VaccineMumps VaccineRubella VaccineVaccines, Combined

Identifiers

PMID7795447
PMCPMC2550008
OpenAlexW2075959165

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.