ArticleAnnals of the rheumatic diseases1995
Magnesium whitlockite deposition in articular cartilage: a study of 80 specimens from 70 patients.
Article in Annals of the rheumatic diseases, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- Calcified nodules in retinal drusen are associated with disease progression in age-related macular degeneration.Science translational medicine · 2018Article
- Basic calcium phosphate crystal-associated musculoskeletal syndromes: an update.Current opinion in rheumatology · 2018Review
- Relationships between pathology and crystal structure in breast calcifications: anNPJ breast cancer · 2016Article
- Vascular Calcification Revisited: A New Perspective for Phosphate TransportCurrent cardiology reviews · 2015Article
- Mineralization of articular cartilage in the Sprague-Dawley rat: characterization and mechanical analysis.Osteoarthritis and cartilage · 2012Article
- Calcium phosphate microcrystal deposition in the human intervertebral disc.Journal of anatomy · 2006Article
- Hydroxyapatite deposition disease of the joint.Current rheumatology reports · 2003Review
- Crystal deposition and osteoarthritis.Current rheumatology reports · 1999Review
- Calcium orthophosphates (CaPOProgress in biomaterialsArticle
- Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine articular cartilage from a number of joint sites, using a large sample group, for the presence of magnesium whitlockite crystal deposition.
methodsArticular cartilage specimens were taken from a total of 70 patients. The majority of specimens were taken from femoral heads, with smaller numbers from femoral condyle, tibial plateau, radius, ulna, and several small peripheral joints. Normal and osteoarthritic articular cartilage specimens were obtained from patients undergoing prosthesis replacement or amputation. Specimens were resin embedded and examined using transmission electron microscopy and x ray microanalysis.
resultsMagnesium whitlockite crystals were identified, on the basis of morphology, size and elemental composition, in articular cartilage from all sites sampled. The distribution of crystals was similar in all samples (restricted to the superficial zone), although the density of deposition was extremely variable, with the greatest density observed in femoral head specimens. No magnesium whitlockite crystals were observed in osteophytic or epiphysial cartilage.
conclusionsThis study demonstrated the widespread extent of magnesium whitlockite deposition in human articular cartilage, albeit at much lower density than previously reported in femoral head articular cartilage. In consideration of possible roles for these crystals in articular cartilage, it is concluded that an opportunistic mode of formation, possibly influenced by mechanical stresses, would be most plausible.
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