ArticleMolecular and cellular biology1995
Interaction of the CCAAT displacement protein with shared regulatory elements required for transcription of paired histone genes.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 51 citations in OpenAlex.
- p110 CUX1 cooperates with E2F transcription factors in the transcriptional activation of cell cycle-regulated genes.Molecular and cellular biology · 2008Article
- HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition.Molecular and cellular biology · 2005Article
- Smad1 and Smad8 function similarly in mammalian central nervous system development.Molecular and cellular biology · 2005Article
- Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- CCAAT displacement protein/cut homolog recruits G9a histone lysine methyltransferase to repress transcription.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Regulation of murine Tap1 and Lmp2 genes in macrophages by interferon gamma is mediated by STAT1 and IRF-1.Genes and immunity · 2004Article
- Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase.Molecular and cellular biology · 2003Article
- A novel colonic repressor element regulates intestinal gene expression by interacting with Cux/CDP.Molecular and cellular biology · 2002Article
- Genetic ablation of the CDP/Cux protein C terminus results in hair cycle defects and reduced male fertility.Molecular and cellular biology · 2002Article
- C/EBP epsilon mediates myeloid differentiation and is regulated by the CCAAT displacement protein (CDP/cut).Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3.Molecular and cellular biology · 2000Article
- The homeodomain transcription factor CDP/cut interacts with the cell cycle regulatory element of histone H4 genes packaged into nucleosomes.Molecular biology reports · 1999Article
- Molecular regulation of beta-lactam biosynthesis in filamentous fungi.Microbiology and molecular biology reviews : MMBR · 1998Review
- The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes.Molecular biology reports · 1998Article
- CDP/cut is the DNA-binding subunit of histone gene transcription factor HiNF-D: a mechanism for gene regulation at the G1/S phase cell cycle transition point independent of transcription factor E2F.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Identification of a major cis-acting DNA element controlling the bidirectionally transcribed penicillin biosynthesis genes acvA (pcbAB) and ipnA (pcbC) of Aspergillus nidulans.Journal of bacteriology · 1996Article
- Identification of a second conserved element within the coding sequence of a mouse H3 histone gene that interacts with nuclear factors and is necessary for normal expression.Nucleic acids research · 1996Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The H2A and H2B genes of the Xenopus xlh3 histone gene cluster are transcribed in opposite directions from initiation points located approximately 235 bp apart. The close proximity of these genes to one another suggests that their expression may be controlled by either a single bidirectional promoter or by separate promoters. Our analysis of the transcription of histone gene pairs containing deletions and site-specific mutations of intergenic DNA revealed that both promoters are distinct but that they overlap physically and share multiple regulatory elements, providing a possible basis for the coordinate regulation of their in vivo activities. Using the intergenic DNA fragment as a probe and extracts from mammalian and amphibian cells, we observed the formation of a specific complex containing the CCAAT displacement protein (CDP). The formation of the CDP-containing complex was not strictly dependent on any single element in the intergenic region but instead required the presence of at least two of the three CCAAT motifs. Interestingly, similar CDP-containing complexes were formed on the promoters from the three other histone genes. The binding of CDP to histone gene promoters may contribute to the coordination of their activities during the cell cycle and early development.
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