ReviewLipids1995
Some new aspects of isoprenoid biosynthesis in plants--a review.
Review in Lipids, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 303 citations in OpenAlex.
- Phytochemistry, Pharmacological Potential, and Future Prospects of Abietane-Type Diterpenoids From Salvia rosmarinus.Chemistry & biodiversity · 2026Review
- Genomic Analysis of Carotenoid and Vitamin E Biosynthetic Pathways in the Extremophilic Red AlgaAntioxidants (Basel, Switzerland) · 2025Article
- Physiological and gene expression analysis of Hevea brasiliensis under drought stress.PloS one · 2025Article
- Updated aspects of alpha-Solanine as a potential anticancer agent: Mechanistic insights and future directions.Food science & nutrition · 2024Review
- Comparative transcriptome and metabolite profiling reveal diverse pattern of CYP-TS gene expression during corosolic acid biosynthesis in Lagerstroemia speciosa (L.) Pers.Plant cell reports · 2024Article
- Heterologous Expression of Three Transcription Factors Differently Regulated Astragalosides Metabolic Biosynthesis inPlants (Basel, Switzerland) · 2022Article
- Genome-Wide Identification and Characterization of CDPK Family Reveal Their Involvements in Growth and Development and Abiotic Stress in Sweet Potato and Its Two Diploid Relatives.International journal of molecular sciences · 2022Article
- Candidate genes and SNPs associated with stomatal conductance under drought stress in Vitis.BMC plant biology · 2021Article
- Proteomic Landscape of the Mature Roots in a Rubber-Producing GrassInternational journal of molecular sciences · 2019Article
- Altered Promoter and G-Box Binding Factor forInternational journal of molecular sciences · 2019Article
- Terpene profiling, transcriptome analysis and characterization ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2019Article
- Genomic discovery of the hypsin gene and biosynthetic pathways for terpenoids in Hypsizygus marmoreus.BMC genomics · 2018Article
- Tracing the biosynthetic origin of limonoids and their functional groups through stable isotope labeling and inhibition in neem tree (Azadirachta indica) cell suspension.BMC plant biology · 2018Article
- Improved fruit α-tocopherol, carotenoid, squalene and phytosterol contents through manipulation of Brassica juncea 3-HYDROXY-3-METHYLGLUTARYL-COA SYNTHASE1 in transgenic tomato.Plant biotechnology journal · 2018Article
- Crystal structure of IspF fromBioscience reports · 2018Article
- The Potential of Isoprenoids in Adjuvant Cancer Therapy to Reduce Adverse Effects of Statins.Frontiers in pharmacology · 2018Review
- Article
- Acyl-CoA-Binding Protein ACBP1 Modulates Sterol Synthesis during Embryogenesis.Plant physiology · 2017Article
- Deep sequencing and transcriptome analyses to identify genes involved in secoiridoid biosynthesis in the Tibetan medicinal plant Swertia mussotii.Scientific reports · 2017Article
- Transcriptome Analysis to Identify the Putative Biosynthesis and Transport Genes Associated with the Medicinal Components ofFrontiers in plant science · 2016Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants are capable of synthesizing a myriad of isoprenoids and prenyl lipids. Much attention has been focused on 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), the enzyme that synthesizes mevalonate and is generally considered responsible for the regulation of substrate flux to isoprenoids. In contrast to vertebrates, where there seems to exist only one HMGR gene, in plants a small family of isogenes appears differentially expressed in regard to location and time. Much less is known in plants about the preceding steps, viz. the conversion of acetyl-CoA to HMG-CoA. An enzyme system has been isolated from radish that can catalyze this transformation, and which shows some unusual properties in vitro. The intracellular localization of the early steps of isoprenoid biosynthesis in plant cells is still a matter of debate. The various observations and hypotheses derived from incorporation and inhibition studies are somewhat contradictory, and an attempt is being made to rationalize various findings that do not at first seem compatible. There are good arguments in favor of an exclusively cytoplasmic formation of isopentenyl pyrophosphate (IPP) via mevalonic acid, but other studies and observations suggest an independent formation in plastids. Other possibilities are being considered, such as the existence of independent (compartmentalized) biosynthetic pathways of IPP formation via the so-called Rohmer pathway. Substrate channeling through the formation of end product-specific multienzyme complexes (metabolons) with no release of substrate intermediates will also be discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.