ArticleThe Journal of experimental medicine1995
Human autoantibody to defensin: disease association with hyperreactive onchocerciasis (sowda).
Article in The Journal of experimental medicine, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 67 citations in OpenAlex.
- Filarial disease in the Brazilian Amazon and emerging opportunities for treatment and control.Current research in parasitology & vector-borne diseases · 2024Review
- Detection of α-defensin in eosinophils in helminth-infected mouse model.The Journal of veterinary medical science · 2018Article
- Wolbachia endosymbionts induce neutrophil extracellular trap formation in human onchocerciasis.Scientific reports · 2016Article
- Human filarial Wolbachia lipopeptide directly activates human neutrophils in vitro.Parasite immunology · 2014Article
- Article
- MRI findings in people with epilepsy and nodding syndrome in an area endemic for onchocerciasis: an observational study.African health sciences · 2013Observational
- Immunohistology of ectopic secondary lymph follicles in subcutaneous nodules from patients with hyperreactive onchocerciasis (sowda).Parasitology research · 2010Article
- Antineutrophil cytoplasmic autoantibodies: how should the biologist manage them?Clinical reviews in allergy & immunology · 2008Review
- Expression of antimicrobial neutrophil defensins in epithelial cells of active inflammatory bowel disease mucosa.Journal of clinical pathology · 2002Article
- Calgranulin C has filariacidal and filariastatic activity.Infection and immunity · 1999Article
- Immunohistochemical localization of defensin in human coronary vessels.The American journal of pathology · 1997Article
- Cloning and sequence analysis of human and bovine corneal antigen (CO-Ag) cDNA: identification of host-parasite protein calgranulin C.Transactions of the American Ophthalmological Society · 1997Article
- Sensitivity of a polymerase chain reaction-based assay to detect Onchocerca volvulus DNA in skin biopsies.Parasitology research · 1996Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic hyperreactive onchodermatitis (sowda) is a severe form of onchocerciasis observed in a subset of individuals infected with the filarial nematode Onchocerca volvulus. SDS-PAGE and immunoblot analyses of O. volvulus adult worm extracts were used to characterize the antigens of the marked antibody response of sowda patients. One 2.5-kD antigen was recognized by sera from all 35(100%) sowda patients that were studied. In comparison, only 7 of 44 (16%) patients with generalized onchocerciasis and 11 of 21 (52%) of exposed individuals with no microfilariae in skin snips and no signs of disease showed reactivity to this antigen. Microfilaricidal treatment of sowda patients with improvement of the clinical status was associated with a decrease or disappearance of antibodies to the 2.5-kD antigen. Amino acid sequencing of the antigen indicated identity to human defensins 1-3 of neutrophils. Defensin was demonstrated by immunohistochemical staining in onchocercal nodules on the surface of adult filariae and in the surrounding tissue. A similar staining pattern was observed for other proteins present in neutrophils such as myeloperoxidase, elastase, and the L-1 protein complex (MRP 8/MRP 14), indicating that neutrophils, macrophages, and their proteins predominate in the environment adjacent to the worms. These results demonstrate an association between the presence of autoantibodies to defensins and an infectious disease of known etiology. The association with a particular form of onchocerciasis, sowda, suggests a link between formation of autoantibodies to defensin and enhanced immune reactivity towards the parasite.
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