ArticleThe Journal of experimental medicine1995
CD43 is a murine T cell costimulatory receptor that functions independently of CD28.
Article in The Journal of experimental medicine, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 135 citations in OpenAlex.
- Differential Impact of CD43 and CD28 on T-Cell Differentiation Depending on the Order of Engagement with the TCR.International journal of molecular sciences · 2024Article
- CD28 shapes T cell receptor signaling by regulating Lck dynamics and ZAP70 activation.Frontiers in immunology · 2024Article
- Transplantation elicits a clonally diverse CD8Cell reports · 2023Article
- CD169+ Monocyte and Regulatory T Cell Subsets Are Associated with Disease Activity in Rheumatoid Arthritis.Journal of personalized medicine · 2022Article
- Changed Expression of Cytoskeleton Proteins During Lung Injury in a Mouse Model ofFrontiers in microbiology · 2018Article
- An alternative mode of CD43 signal transduction activates pro-survival pathways of T lymphocytes.Immunology · 2017Article
- Engagement of distinct epitopes on CD43 induces different co-stimulatory pathways in human T cells.Immunology · 2016Article
- CD43-mediated IFN-γ production by CD8+ T cells promotes abdominal aortic aneurysm in mice.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Role of unusual CD4+ CD28- T cells in acute coronary syndrome.Molecular biology reports · 2012Review
- Article
- CD43 Expression Regulated by IL-12 Signaling Is Associated with Survival of CD8 T Cells.Immune network · 2010Article
- Deletion of PI3K-p85alpha gene impairs lineage commitment, terminal maturation, cytokine generation and cytotoxicity of NK cells.Genes and immunity · 2008Article
- T-cell activation in the intestinal mucosa.Immunological reviews · 2007Review
- CD43-independent augmentation of mouse T-cell function by glycoprotein cleaving enzymes.Immunology · 2006Article
- Upregulation of ICOS on CD43+ CD4+ murine small intestinal intraepithelial lymphocytes during acute reovirus infection.Biochemical and biophysical research communications · 2006Article
- Selective upregulation of immune regulatory and effector cytokine synthesis by intestinal intraepithelial lymphocytes following CD43 costimulation.Biochemical and biophysical research communications · 2005Article
- Activation and Costimulation of Intestinal T Cells: Independent and Collaborative Involvement of CD43, OX40, and Ly-6C.Current immunology reviews · 2005Article
- CD43 regulation of T cell activation is not through steric inhibition of T cell-APC interactions but through an intracellular mechanism.The Journal of experimental medicine · 2004Article
- T-cell activation in the curious world of the intestinal intraepithelial lymphocyte.Immunologic research · 2004Review
- A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43.The Journal of experimental medicine · 2000Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Costimulation mediated by the CD28 receptor has been shown to play an important role in the development of a vigorous T cell immune response. Nevertheless, CD28-deficient mice can mount effective T cell-dependent immune responses. These data suggest that other costimulatory molecules may play a role in T cell activation. In a search for other costimulatory receptors on T cells, we have characterized a monoclonal antibody (mAb) that can costimulate T cells in the absence of accessory cells. Similar to CD28 antibodies, this mAb, R2/60, was found to synergize with T cell receptor engagement in inducing proliferation. Independent ligation of CD3 and the ligand recognized by R2/60 results in T cell proliferation, suggesting that the two molecules do not have to colocalize to activate the R2/60 costimulatory pathway. R2/60 does not react with CD28, and furthermore, R2/60 costimulates in a CD28-independent fashion since the mAb costimulates T cells from the CD28-deficient mice as well as wild-type mice. Expression cloning of the R2/60 antigen identified the ligand as murine CD43. Together, these data demonstrate that CD43 can serve as a receptor on T cells that can provide CD28-independent costimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.