ReviewIntensive care medicine1995
Neutrophil-mediated tissue injury and its modulation.
Review in Intensive care medicine, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed.
- Resuscitation of traumatic hemorrhagic shock patients with hypertonic saline-without dextran-inhibits neutrophil and endothelial cell activation.Shock (Augusta, Ga.) · 2012Trial
- Immunoengineered mitochondria for efficient therapy of acute organ injuries via modulation of inflammation and cell repair.Science advances · 2025Article
- Research on Pachymaran to Ameliorate CsA-Induced Immunosuppressive Lung Injury by Regulating Microflora Metabolism.Microorganisms · 2023Article
- Toll-Like Receptor 2 Modulates Pulmonary Inflammation and TNF-α Release Mediated byFrontiers in cellular and infection microbiology · 2022Article
- Gut Microbiota Characteristics Are Associated With Severity of Acute Radiation-Induced Esophagitis.Frontiers in microbiology · 2022Article
- Nanotherapeutics in the treatment of acute respiratory distress syndrome.Life sciences · 2021Review
- Elevated Systemic and Intestinal Inflammatory Response Are Associated With Gut Microbiome Disorder After Cardiovascular Surgery.Frontiers in microbiology · 2021Article
- More friend than foe: the emerging role of neutrophils in tissue repair.The Journal of clinical investigation · 2019Review
- Sulfur dioxide reduces lipopolysaccharide-induced acute lung injury in rats.Central-European journal of immunology · 2019Article
- Neutrophil phenotypes in health and disease.European journal of clinical investigation · 2018Review
- Effects of Probiotic (Sports (Basel, Switzerland) · 2018Article
- Organ dysfunction as a new standard for defining sepsis.Inflammation and regeneration · 2016Review
- A Neutrophil Phenotype Model for Extracorporeal Treatment of Sepsis.PLoS computational biology · 2015Article
- Myristoylated Alanine Rich C Kinase Substrate (MARCKS) is essential to β2-integrin dependent responses of equine neutrophils.Veterinary immunology and immunopathology · 2014Article
- Pathophysiology and biomarkers of acute respiratory distress syndrome.Journal of intensive care · 2014Review
- The adaptive immune response does not influence hantavirus disease or persistence in the Syrian hamster.Immunology · 2013Article
- A myristoylated alanine-rich C kinase substrate-related peptide suppresses cytokine mRNA and protein expression in LPS-activated canine neutrophils.American journal of respiratory cell and molecular biology · 2013Article
- Sulfur dioxide attenuates LPS-induced acute lung injury via enhancing polymorphonuclear neutrophil apoptosis.Acta pharmacologica Sinica · 2012Article
- Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones.PloS one · 2012Article
- Preventive effects of valnemulin on lipopolysaccharide-induced acute lung injury in mice.Inflammation · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neutrophils play a key role in the development of the systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). Since the lungs are the main target in these syndromes, with adult respiratory distress syndrome (ARDS) as the outcome, extensive research has been undertaken to prevent or mitigate ARDS. As evidence of the involvement of neutrophils in ARDS has accumulated, modulation of their function has become a major goal in terms of a therapeutic approach. In this short review, we sought to update our knowledge about neutrophils. Firstly, we summarized the various stimuli which activate neutrophils. Secondly, we described the different mediators, including cytokines, which are released by neutrophils. Lastly, we discussed the possible modulation of their function. Although we cannot assess the clinical usefulness of biochemical substances merely on the basis of their in vitro effects, understanding these mechanisms is fundamental to the success of the new therapeutic approach which is currently under way.
Indexed as
Identifiers
7790621What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.