ArticleThe Journal of cell biology1995
The 95F unconventional myosin is required for proper organization of the Drosophila syncytial blastoderm.
Article in The Journal of cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 95 citations in OpenAlex.
- Myosin VI is expressed in developing ovarian follicles inFrontiers in cell and developmental biology · 2025Article
- Diverse functions of myosin VI in spermiogenesis.Histochemistry and cell biology · 2021Review
- Loss of myosin VI expression affects acrosome/acroplaxome complex morphology during mouse spermiogenesis†.Biology of reproduction · 2020Article
- Coordination of Embryogenesis by the Centrosome in Drosophila melanogaster.Results and problems in cell differentiation · 2019Review
- Myosin VI contributes to synaptic transmission and development at the Drosophila neuromuscular junction.BMC neuroscience · 2011Article
- Multifunctional myosin VI has a multitude of cargoes.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Proteomics approach to study the functions of Drosophila myosin VI through identification of multiple cargo-binding proteins.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Potential roles of myosin VI in cell motility.Biochemical Society transactions · 2009Review
- A novel role for an APC2-Diaphanous complex in regulating actin organization in Drosophila.Development (Cambridge, England) · 2009Article
- Genetic characterization of the Drosophila jaguar322 mutant reveals that complete myosin VI loss of function is not lethal.Genetics · 2008Article
- Mining phenotypes for gene function prediction.BMC bioinformatics · 2008Article
- Myosin VI stabilizes an actin network during Drosophila spermatid individualization.Molecular biology of the cell · 2006Article
- A monomeric myosin VI with a large working stroke.The EMBO journal · 2004Article
- Reassessing the role and dynamics of nonmuscle myosin II during furrow formation in early Drosophila embryos.Molecular biology of the cell · 2004Article
- Actin cytoskeleton remodeling during early Drosophila furrow formation requires recycling endosomal components Nuclear-fallout and Rab11.The Journal of cell biology · 2003Article
- Mutations of MYO6 are associated with recessive deafness, DFNB37.American journal of human genetics · 2003Article
- MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice, is mutated in autosomal dominant nonsyndromic hearing loss.American journal of human genetics · 2001Article
- Myosin VI: roles for a minus end-directed actin motor in cells.The Journal of cell biology · 2000Review
- Class VI unconventional myosin is required for spermatogenesis in Drosophila.Molecular biology of the cell · 1999Article
- Association of myosin I alpha with endosomes and lysosomes in mammalian cells.Molecular biology of the cell · 1999Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The 95F myosin, a class VI unconventional myosin, associates with particles in the cytoplasm of the Drosophila syncytial blastoderm and is required for the ATP- and F-actin-dependent translocation of these particles. The particles undergo a cell cycle-dependent redistribution from domains that surround each nucleus in interphase to transient membrane invaginations that provide a barrier between adjacent spindles during mitosis. When 95F myosin function is inhibited by antibody injection, profound defects in syncytial blastoderm organization occur. This disorganization is seen as aberrant nuclear morphology and position and is suggestive of failures in cytoskeletal function. Nuclear defects correlate with gross defects in the actin cytoskeleton, including indistinct actin caps and furrows, missing actin structures, abnormal spacing of caps, and abnormally spaced furrows. Three-dimensional examination of embryos injected with anti-95F myosin antibody reveals that actin furrows do not invaginate as deeply into the embryo as do normal furrows. These furrows do not separate adjacent mitoses, since microtubules cross over them. These inappropriate microtubule interactions lead to aberrant nuclear divisions and to the nuclear defects observed. We propose that 95F myosin function is required to generate normal actin-based transient membrane furrows. The motor activity of 95F myosin itself and/or components within the particles transported to the furrows by 95F myosin may be required for normal furrows to form.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.