ArticleThe Journal of cell biology1995
Oligomerized transferrin receptors are selectively retained by a lumenal sorting signal in a long-lived endocytic recycling compartment.
Article in The Journal of cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 151 citations in OpenAlex.
- A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro.Scientific reports · 2024Article
- Standardized PreclinicalMolecular pharmaceutics · 2023Article
- Receptor-mediated drug delivery of bispecific therapeutic antibodies through the blood-brain barrier.Frontiers in drug delivery · 2023Article
- Uptake, functionality, and re-release of extracellular vesicle-encapsulated cargo.Cell reports · 2022Article
- The Alzheimer's gene SORL1 is a regulator of endosomal traffic and recycling in human neurons.Cellular and molecular life sciences : CMLS · 2022Article
- Bispecific antibodies with Fab-arms featuring exchanged antigen-binding constant domains.Biochemistry and biophysics reports · 2021Article
- Mathematical modeling of drug-induced receptor internalization in the HER2-positive SKBR3 breast cancer cell-line.Scientific reports · 2019Article
- Membrane Transport across Polarized Epithelia.Cold Spring Harbor perspectives in biology · 2017Review
- Intra- and trans-cellular delivery of enzymes by direct conjugation with non-multivalent anti-ICAM molecules.Journal of controlled release : official journal of the Controlled Release Society · 2016Article
- Targeting prion-like protein doppel selectively suppresses tumor angiogenesis.The Journal of clinical investigation · 2016Article
- The endocytic recycling compartment maintains cargo segregation acquired upon exit from the sorting endosome.Molecular biology of the cell · 2016Article
- Recycling endosomes.Current opinion in cell biology · 2015Review
- Distinct subcellular trafficking resulting from monomeric vs multimeric targeting to endothelial ICAM-1: implications for drug delivery.Molecular pharmaceutics · 2014Article
- Sorting of β1-adrenergic receptors is mediated by pathways that are either dependent on or independent of type I PDZ, protein kinase A (PKA), and SAP97.The Journal of biological chemistry · 2014Article
- Comparative analysis of disease pathogenesis and molecular mechanisms of New World and Old World arenavirus infections.The Journal of general virology · 2014Review
- Reprogramming of G protein-coupled receptor recycling and signaling by a kinase switch.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Multivalent immune complexes divert FcRn to lysosomes by exclusion from recycling sorting tubules.Molecular biology of the cell · 2013Article
- Encounter with antigen-specific primed CD4 T cells promotes MHC class II degradation in dendritic cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Mass spectrometry study of a transferrin-based protein drug reveals the key role of protein aggregation for successful oral delivery.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Patterned cell adhesion associated with tissue deformations during dorsal closure in Drosophila.PloS one · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cross-linking of surface receptors results in altered receptor trafficking in the endocytic system. To better understand the cellular and molecular mechanisms by which receptor cross-linking affects the intracellular trafficking of both ligand and receptor, we studied the intracellular trafficking of the transferrin receptor (TfR) bound to multivalent-transferrin (Tf10) which was prepared by chemical cross-linking of transferrin (Tf). Tf10 was internalized about two times slower than Tf and was retained four times longer than Tf, without being degraded in CHO cells. The intracellular localization of Tf10 was investigated using fluorescence and electron microscopy. Tf10 was not delivered to the lysosomal pathway followed by low density lipoprotein but remained accessible to Tf in the pericentriolar endocytic recycling compartment for at least 60 min. The retained Tf10 was TfR-associated as demonstrated by a reduction in surface TfR number when cells were incubated with Tf10. The presence of Tf10 within the recycling compartment did not affect trafficking of subsequently endocytosed Tf. Retention of Tf10 within the recycling compartment did not require the cytoplasmic domain of the TfR since Tf10 exited cells with the same rate when bound to the wild-type TfR or a mutated receptor with only four amino acids in the cytoplasmic tail. Thus, cross-linking of surface receptors by a multivalent ligand acts as a lumenal retention signal within the recycling compartment. The data presented here show that the recycling compartment labeled by Tf10 is a long-lived organelle along the early endosome recycling pathway that remains fusion accessible to subsequently endocytosed Tf.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.