ArticleInfection and immunity1995
Role of Yops in inhibition of phagocytosis and killing of opsonized Yersinia enterocolitica by human granulocytes.
Article in Infection and immunity, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 66 citations in OpenAlex.
- Review
- Going around in circles: virulence plasmids in enteric pathogens.Nature reviews. Microbiology · 2018Review
- Yersinia pseudotuberculosis Blocks Neutrophil Degranulation.Infection and immunity · 2016Article
- Yersinia virulence factors - a sophisticated arsenal for combating host defences.F1000Research · 2016Review
- Spatially distinct neutrophil responses within the inflammatory lesions of pneumonic plague.mBio · 2015Article
- ¹H, ¹⁵N, and ¹³C backbone resonance assignments for the Yersinia protein tyrosine phosphatase YopH.Biomolecular NMR assignments · 2014Article
- Yersinia pseudotuberculosis uses Ail and YadA to circumvent neutrophils by directing Yop translocation during lung infection.Cellular microbiology · 2014Article
- The impact of Toll-like receptors on bacterial virulence strategies.Current opinion in microbiology · 2013Review
- Role of YopK in Yersinia pseudotuberculosis resistance against polymorphonuclear leukocyte defense.Infection and immunity · 2013Article
- Yersinia infection tools-characterization of structure and function of adhesins.Frontiers in cellular and infection microbiology · 2012Review
- Human polymorphonuclear neutrophil responses to Burkholderia pseudomallei in healthy and diabetic subjects.Infection and immunity · 2009Article
- Yersinia pestis type III secretion system-dependent inhibition of human polymorphonuclear leukocyte function.Infection and immunity · 2008Article
- Intranasal inoculation of mice with Yersinia pseudotuberculosis causes a lethal lung infection that is dependent on Yersinia outer proteins and PhoP.Infection and immunity · 2007Article
- Modulation of complement activity in vitro and in vivo by Yersinia wild and mutant strains.Folia microbiologica · 2006Article
- YscP and YscU regulate substrate specificity of the Yersinia type III secretion system.Journal of bacteriology · 2003Article
- Yersinia type III secretion: send in the effectors.The Journal of cell biology · 2002Review
- Role of Yops and adhesins in resistance of Yersinia enterocolitica to phagocytosis.Infection and immunity · 2002Article
- Characterization of the interaction between Yersinia enterocolitica biotype 1A and phagocytes and epithelial cells in vitro.Infection and immunity · 1999Article
- LcrV of Yersinia pestis enters infected eukaryotic cells by a virulence plasmid-independent mechanism.Infection and immunity · 1999Article
- Yersinia pseudotuberculosis-induced calcium signaling in neutrophils is blocked by the virulence effector YopH.Infection and immunity · 1999Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The virulence plasmid of Yersinia enterocolitica codes for the production of the outer membrane protein YadA and the secretion of several proteins, called Yops, which may play a role in the interaction between granulocytes and this bacterium. We investigated whether the expression of YadA or the secretion of Yops affected the phagocytosis and killing of opsonized Y. enterocolitica by human granulocytes. The rates of phagocytosis and killing of Y. enterocolitica by granulocytes in suspension in the presence of rabbit Yersinia antibodies and complement were determined by microbiological assays. In addition, noningested cell-adherent bacteria were differentiated from ingested yersiniae by immunofluorescence microscopy. Plasmid-bearing opsonized Y. enterocolitica was able to inhibit phagocytosis and killing by human granulocytes. The inhibition of phagocytosis was specific for the plasmid-bearing strain of Y. enterocolitica, since granulocytes were still able to phagocytose and kill Staphylococcus aureus in the presence of Y. enterocolitica. Plasmid-cured Y. enterocolitica was readily phagocytosed and killed by these cells. To investigate the role of YadA or Yops in the inhibition of phagocytosis by granulocytes, the phagocytosis of mutant strains unable to express YadA or to secrete Yops was studied. A Y. enterocolitica mutant unable to secrete Yops lost its ability to inhibit phagocytosis; a mutant expressing only YadA was readily ingested by granulocytes. These results indicate that after attachment of opsonized Y. enterocolitica to granulocytes, Yops play an important role in inhibiting the ingestion of Y. enterocolitica by human granulocytes.
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