ArticleGenetics1995
Interval mapping of high growth (hg), a major locus that increases weight gain in mice.
Article in Genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 54 citations in OpenAlex.
- Genetic Dissection of a QTL Affecting Bone Geometry.G3 (Bethesda, Md.) · 2017Article
- Genomic mapping of social behavior traits in a F2 cross derived from mice selectively bred for high aggression.BMC genetics · 2010Article
- Genetic dissection of a major mouse obesity QTL (Carfhg2): integration of gene expression and causality modeling.Physiological genomics · 2009Article
- Overexpression of Scg5 increases enzymatic activity of PCSK2 and is inversely correlated with body weight in congenic mice.BMC genetics · 2008Article
- Article
- Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains.BMC genomics · 2006Article
- Functional mapping of quantitative trait loci that interact with the hg mutation to regulate growth trajectories in mice.Genetics · 2005Article
- Quantitative trait loci affecting body weight and fatness from a mouse line selected for extreme high growth.Genetics · 1998Article
- Article
- Fine genetic mapping of the region surrounding the high growth (hg) locus in mouse chromosome 10: targeting random amplified polymorphic DNA (RAPD) markers.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- Article
- QTL underlying voluntary exercise in mice: interactions with the "mini muscle" locus and sex.The Journal of heredityArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The high growth locus (hg) causes a major increase in weight gain and body size in mice. As a first step to map-based cloning of hg, we developed a genetic map of the hg-containing region using interval mapping of 403 F2 from a C57BL/6J-hghg x CAST/EiJ cross. The maximum likelihood position of hg was at the chromosome 10 marker D10Mit41 (LOD = 24.8) in the F2 females and 1.5 cM distal to D10Mit41 (LOD = 9.56) in the F2 males with corresponding LOD 2 support intervals of 3.7 and 5.4 cM, respectively. The peak LOD scores were significantly higher than the estimated empirical threshold LOD values. The localization of hg by interval mapping was supported by a test cross of F2 mice recombinant between the LOD 2 support interval and the flanking marker. The interval mapping and test-cross results indicate that hg is not allelic with candidate genes Igf1 or decorin (Dcn), a gene that was mapped close to hg in this study. The hg inheritance was recessive in females, although we could not reject recessive or additive inheritance in males. Possible causes for sex differences in peak LOD scores and for the distortion of transmission ratios observed in F2 males are discussed. The genetic map of the hg region will facilitate further fine mapping and cloning of hg, and allow searches for a homologous quantitative trait locus affecting growth in humans and domestic animals.
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