ArticleGenetics1995
Horka, a dominant mutation of Drosophila, induces nondisjunction and, through paternal effect, chromosome loss and genetic mosaics.
Article in Genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Control of mating plug expelling and sperm storage in Drosophila: A gynandromorph- and mutation-based dissection.Biologia futura · 2019Article
- An assay to detect in vivo Y chromosome loss in Drosophila wing disc cells.G3 (Bethesda, Md.) · 2012Article
- HorkaD, a chromosome instability-causing mutation in Drosophila, is a dominant-negative allele of Lodestar.Genetics · 2009Article
- Modifiers of epigenetic reprogramming show paternal effects in the mouse.Nature genetics · 2007Article
- A genetic and mosaic analysis of a locus involved in the anesthesia response of Drosophila melanogaster.Genetics · 1997Article
- Expression of Drosophila mushroom body mutations in alternative genetic backgrounds: a case study of the mushroom body miniature gene (mbm).Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Localization of pheromonal sexual dimorphism in Drosophila melanogaster and its effect on sexual isolation.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
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3 authors.
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Abstract
Fs(3)Horka (Horka) was described as a dominant female-sterile mutation of Drosophila melanogaster. Genetic and cytological data show that Horka induces mostly equational nondisjunction during spermatogenesis but not chromosome loss and possesses a dominant paternal effect: the X, second, third and the fourth chromosomes, but not the Y, are rendered unstable while undergoing spermatogenesis and may be lost in the descending zygotes. The frequency of Horka-induced chromosome loss is usually 2-4% but varies with the genetic background and can be over 20%. The X chromosome loss occurs during the gonomeric and the initial cleavage divisions. Loss of the X and fourth chromosomes shows no correlation. We propose, based on similarities in the mutant phenotypes with the chromosome destabilizing mutations nonclaret disjunctional and paternal loss, that the normal Horka+ product is required for function of the centromeres and/or nearby regions. Horka is a convenient tool for the generation of gynandromorphs, autosome mosaics and for the study of gene expression in mosaics.
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