ArticleMolecular biology of the cell1995
Molecular cloning and characterization of human kinectin.
Article in Molecular biology of the cell, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 50 citations in OpenAlex.
- Variant-specific interaction of kinectin 1 with the multi-tRNA synthetase complex regulates ER sheet organization.iScience · 2026Article
- CDR2 is a dynein adaptor recruited by kinectin to regulate ER sheet organization.The Journal of cell biology · 2025Article
- Rab18 regulates focal adhesion dynamics by interacting with kinectin-1 at the endoplasmic reticulum.The Journal of cell biology · 2020Article
- Comprehensive Genetic Landscape of Uveal Melanoma by Whole-Genome Sequencing.American journal of human genetics · 2016Article
- Fusion genes with ALK as recurrent partner in ependymoma-like gliomas: a new brain tumor entity?Neuro-oncology · 2015Article
- Cell membrane proteomic analysis identifies proteins differentially expressed in osteotropic human breast cancer cells.Neoplasia (New York, N.Y.) · 2008Article
- Identification of kinectin as a novel Behçet's disease autoantigen.Arthritis research & therapy · 2005Article
- Intact lysosome transport and phagosome function despite kinectin deficiency.Molecular and cellular biology · 2001Article
- Quality assessment of whole genome mapping data in the refined familial spastic paraplegia interval on chromosome 14q.Genome research · 1998Article
- Kinesin light chains are essential for axonal transport in Drosophila.The Journal of cell biology · 1998Article
- KLP38B: a mitotic kinesin-related protein that binds PP1.The Journal of cell biology · 1997Article
- Molecular requirements for bi-directional movement of phagosomes along microtubules.The Journal of cell biology · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have identified a human cDNA that is homologous to the chicken kinectin, a putative receptor for the organelle motor kinesin. The human cDNA clone hybridized to a single 4.6-kb mRNA species that codes for a protein of 156 kDa molecular mass. The predicted primary translation product contains an N-terminal transmembrane helix followed by a bipartite nuclear localization sequence and two further C-terminal leucine zipper motifs. In addition, the aminoacid sequence revealed a large region (327-1362) of predicted alpha-helical coiled coils. A monoclonal antibody CT-1 raised against a GST-kinectin fusion protein produced a perinuclear, endoplasmic reticulum-like staining pattern in diverse cell types from different species, indicating evolutionary conservation. Monoclonal antibody CT-1 and anti-chicken kinectin antibodies cross-reacted both in Western blotting and immunoprecipitation with a 160-kDa protein, confirming the antigenic identity of this 160-kDa protein with chicken kinectin. Epitope tagging studies revealed that the nuclear localization sequence motif of kinectin is not functional. Furthermore, a truncated kinesin cDNA lacking the N-terminal hydrophobic domain revealed a nonspecific cytoplasmic staining pattern. Together the data suggest that kinectin is an integral membrane protein anchored in the endoplasmic reticulum via a transmembrane domain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.