ArticleBiophysical journal1995
Intracellular calcium levels correlate with speed and persistent forward motion in migrating neutrophils.
Article in Biophysical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 80 citations in OpenAlex.
- Distribution of intracellular calcium during flow-induced migration of RAW264.7 cells.Mechanobiology in medicine · 2024Article
- Advances in Intracellular Calcium Signaling Reveal Untapped Targets for Cancer Therapy.Biomedicines · 2021Review
- Manipulation of cell migration by laserporation-induced local wounding.Scientific reports · 2019Article
- The impact of temporal sampling resolution on parameter inference for biological transport models.PLoS computational biology · 2018Article
- Collective cell migration has distinct directionality and speed dynamics.Cellular and molecular life sciences : CMLS · 2017Article
- Ca2+ signaling in cytoskeletal reorganization, cell migration, and cancer metastasis.BioMed research international · 2015Review
- Glutamate involvement in calcium-dependent migration of astrocytoma cells.Cancer cell international · 2014Article
- Human embryonic stem cell-derived cardiomyocytes migrate in response to gradients of fibronectin and Wnt5a.Stem cells and development · 2013Article
- Molecular mechanisms of spontaneous and directed mast cell motility.Journal of leukocyte biology · 2012Article
- Blockade of leukocyte haptokinesis and haptotaxis by ketoprofen, diclofenac and SC-560.BMC immunology · 2011Article
- Ceramide-1-phosphate in phagocytosis and calcium homeostasis.Advances in experimental medicine and biology · 2010Review
- Ca2+ influx and phosphoinositide signalling are essential for the establishment and maintenance of cell polarity in monospores from the red alga Porphyra yezoensis.Journal of experimental botany · 2009Article
- TRPC1 channels regulate directionality of migrating cells.Pflugers Archiv : European journal of physiology · 2008Article
- The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151.Cancer cell · 2008Article
- Ca2+ influx is an essential component of the positive-feedback loop that maintains leading-edge structure and activity in macrophages.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- alpha3alpha5beta2-Nicotinic acetylcholine receptor contributes to the wound repair of the respiratory epithelium by modulating intracellular calcium in migrating cells.The American journal of pathology · 2006Article
- Chaotic behavior in the locomotion of Amoeba proteus.Protoplasma · 2001Article
- Biological activities of C3 beta c, a novel neutrophil chemoattractant derived from the beta-chain of rat complement C3.Immunology · 1998Article
- Inversely correlated cycles in speed and turning in an ameba: an oscillatory model of cell locomotion.Biophysical journal · 1997Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The relationship between cytosolic free calcium concentration ([Ca2+]i) and human neutrophil motility was studied by video microscopy. Neutrophils stimulated by a uniform concentration of an N-formylated peptide chemoattractant (f-Met-Leu-Phe) were tracked during chemokinetic migration on albumin, fibronectin, and vitronectin. [Ca2+]i buffering with quin2 resulted in significant decreases in mean speed on albumin. To further characterize the relationship between [Ca2+]i changes and motility we carried out a cross-correlation analysis of [Ca2+]i with several motility parameters. Cross-correlations between [Ca2+]i and each cell's speed, angle changes, turn strength, and persistent forward motion revealed (i) a positive correlation between [Ca2+]i and cell speed (p < 0.05), (ii) no significant correlation between turns and calcium spikes, and (iii) the occurrence of turns during periods of low speed. Significant negative correlations between [Ca2+]i and angle change were noted on the high adhesion substrates vitronectin and fibronectin but not on the low adhesion substrate albumin. These data imply that there is a general temporal relationship between [Ca2+]i, speed, and persistent motion. However, the correlations are not sufficiently strong to imply that changes in [Ca2+]i are required proximal signals for velocity changes.
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