ArticleInternational journal of experimental pathology1995
Sexually differentiated response to choline in choline deficiency and ethionine intoxication.
Article in International journal of experimental pathology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed, 28 citations in OpenAlex.
- Sex and menopausal status influence human dietary requirements for the nutrient choline.The American journal of clinical nutrition · 2007Trial
- Review
- Article
- TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine composition and promote the progression of non-alcoholic steatohepatitis.Nature communications · 2022Article
- Formyl peptide receptor 2 determines sex-specific differences in the progression of nonalcoholic fatty liver disease and steatohepatitis.Nature communications · 2022Article
- Possible Role of Phosphatidylcholine and Sphingomyelin on Fumonisin B1-mediated Toxicity.Food safety (Tokyo, Japan) · 2017Review
- Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2007Article
- The fetal origins of memory: the role of dietary choline in optimal brain development.The Journal of pediatrics · 2006Review
- Choline: critical role during fetal development and dietary requirements in adults.Annual review of nutrition · 2006Review
- Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD).FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A sex difference exists in the response of rats to a choline deficient diet and to ethionine intoxication. Female rats are less susceptible than males to the acute effects of choline deficiency, such as fatty liver and impaired secretion of triglycerides into blood plasma, while they are more susceptible to inhibition of liver protein synthesis and triglyceride accumulation by ethionine. These differences have been ascribed to sex differences in the biosynthesis of phosphatidylcholine in the liver of rats. The available data indicate that females are more dependent than males on the stepwise methylation of phosphatidylethanolamine rather than the direct incorporation of preformed choline. Continuous prefeeding with choline for three weeks was able to shift the female pattern of response to choline deficiency and ethionine intoxication towards that observed in males; thus, choline caused accumulation of hepatic triglycerides and a decrease in plasma triglycerides after choline deficiency, while it protected against ethionine induced triglyceride accumulation and protein synthesis inhibition in the liver. These results suggest that choline prefeeding in females makes them more dependent on choline availability and, thus, more susceptible to a choline deficient diet and less sensitive to ethionine intoxication, as are males. No effect of choline was observed in either choline deficient or ethionine intoxicated male rats.
Indexed as
Identifiers
7786762PMC1997157W214764791What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.