ArticleNucleic acids research1995
A novel initiator regulates expression of the nontissue-specific helix-loop-helix gene ME1.
Article in Nucleic acids research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 10 citations in OpenAlex.
- Transcription initiation from a poly(dA) tract.Nucleic acids research · 1998Article
- ALF1, a basic helix-loop-helix transcription factor, maps to mouse chromosome 9.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- Cloning and chromosomal assignment of the bovine interleukin-2 receptor alpha (IL-2R alpha) gene.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The mouse ME1 gene (HEB, REB and GE1, homologues in human, rat and chick, respectively) is a member of the nontissue-specific helix-loop-helix (HLH) gene family that includes E2A, E2-2 and Drosophila daughterless. We have examined the factors that control ME1 gene expression. ME1 is a single copy gene that spans > or = 150 kb of DNA and contains > 10 exons. Transcription was directed by an unusual initiator element that contained a 13 bp poly d(A) tract flanked by palindromic and inverted repeat sequences. Both RNase protection and primer extension analyses mapped the ME1 transcriptional start site to the center of the 13 bp poly d(A) tract. The ME1 initiator and its proximal sequences were required for promoter activity, supported basal levels of transcription, and contributed to cell type-specific gene expression. Other cis-elements utilized by the TATA-less ME1 promoter included a cluster of Sp1 response elements, E-boxes and a strong repressor. Collectively, our results suggest that the ME1 initiator and other cis-elements in the proximal promoter play an important role in regulating ME1 gene expression.
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Registered trials
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