ReviewJournal of molecular evolution1995
Speculations on the origin of the genetic code.
Review in Journal of molecular evolution, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 80 citations in OpenAlex.
- RNP-world: The ultimate essence of life is a ribonucleoprotein process.Genetics and molecular biology · 2022Article
- Possible Ancestral Functions of the Genetic and RNA Operational Precodes and the Origin of the Genetic System.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2021Article
- First arrived, first served: competition between codons for codon-amino acid stereochemical interactions determined early genetic code assignments.Die Naturwissenschaften · 2020Article
- The primordial tRNA acceptor stem code from theoretical minimal RNA ring clusters.BMC genetics · 2020Article
- Codon Directional Asymmetry Suggests Swapped Prebiotic 1st and 2nd Codon Positions.International journal of molecular sciences · 2020Article
- More Pieces of Ancient than Recent Theoretical Minimal Proto-tRNA-Like RNA Rings in Genes Coding for tRNA Synthetases.Journal of molecular evolution · 2019Article
- Emergence of a "Cyclosome" in a Primitive Network Capable of Building "Infinite" Proteins.Life (Basel, Switzerland) · 2019Article
- Protein Sequences Recapitulate Genetic Code Evolution.Computational and structural biotechnology journal · 2018Article
- Hypothesis of Lithocoding: Origin of the Genetic Code as a "Double Jigsaw Puzzle" of Nucleobase-Containing Molecules and Amino Acids Assembled by Sequential Filling of Apatite Mineral Cellules.Journal of molecular evolution · 2016Article
- Coevolution Theory of the Genetic Code at Age Forty: Pathway to Translation and Synthetic Life.Life (Basel, Switzerland) · 2016Article
- Extraordinarily adaptive properties of the genetically encoded amino acids.Scientific reports · 2015Article
- An Interpretation of the Ancestral Codon from Miller's Amino Acids and Nucleotide Correlations in Modern Coding Sequences.Bioinformatics and biology insights · 2015Article
- On the organizational dynamics of the genetic code.Genomics, proteomics & bioinformatics · 2011Article
- Was Wright right? The canonical genetic code is an empirical example of an adaptive peak in nature; deviant genetic codes evolved using adaptive bridges.Journal of molecular evolution · 2010Review
- Inferring the ancient history of the translation machinery and genetic code via recapitulation of ribosomal subunit assembly orders.PloS one · 2010Article
- A four-column theory for the origin of the genetic code: tracing the evolutionary pathways that gave rise to an optimized code.Biology direct · 2009Article
- Evolutionary patterns in the sequence and structure of transfer RNA: a window into early translation and the genetic code.PloS one · 2008Article
- On the structural regularity in nucleobases and amino acids and relationship to the origin and evolution of the genetic code.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2005Article
- A mechanism for the association of amino acids with their codons and the origin of the genetic code.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Artificially ambiguous genetic code confers growth yield advantage.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The most primitive code is assumed to be a GC code: GG coding for glycine, CC coding for proline, GC coding for alanine, CG coding for "arginine." The genetic code is assumed to have originated with the coupling of glycine to its anticodon CC mediated by a copper-montmorillonite. The polymerization of polyproline followed when it was coupled to its anticodon GG. In this case the aminoacyl-tRNA synthetase was a copper-montmorillonite. The first membrane is considered to be a beta sheet formed from polyglycine. As the code grew more complicated, the alternative hydrophobic-hydrophilic polypeptide (alanine-"arginine") was coded for by the alternating CG copolymer. This alternating polypeptide (ala-"arg") began to function as both a primitive membrane and as an aminoacyl-tRNA synthetase. The evolution of protein structure is tightly coupled to the evolution of the membrane. The alpha helix was evolved as lipids became part of the structure of biological membranes. The membrane finally became the fluid mosaic structure that is now universal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.