ArticleBritish journal of cancer1995
Expression of fibronectin, fibronectin isoforms and integrin receptors in melanocytic lesions.
Article in British journal of cancer, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 50 citations in OpenAlex.
- Review
- EDB Fibronectin-Specific SPECT ProbeACS omega · 2017Article
- Tenascin-C-derived peptide TNIIIA2 highly enhances cell survival and platelet-derived growth factor (PDGF)-dependent cell proliferation through potentiated and sustained activation of integrin α5β1.The Journal of biological chemistry · 2014Article
- Article
- Survivin enhances motility of melanoma cells by supporting Akt activation and {alpha}5 integrin upregulation.Cancer research · 2010Article
- Biomarkers: the useful and the not so useful--an assessment of molecular prognostic markers for cutaneous melanoma.The Journal of investigative dermatology · 2010Article
- The monoclonal antibody SM5-1 recognizes a fibronectin variant which is widely expressed in melanoma.BMC cancer · 2006Article
- Article
- Human melanoma progression in skin reconstructs : biological significance of bFGF.The American journal of pathology · 2000Article
- Expression of fibronectin isoforms in human breast tissue: production of extra domain A+/extra domain B+ by cancer cells and extra domain A+ by stromal cells.Japanese journal of cancer research : Gann · 1999Article
- Adenoviral gene transfer of beta3 integrin subunit induces conversion from radial to vertical growth phase in primary human melanoma.The American journal of pathology · 1998Article
- Detection of altered adhesion molecule expression in experimental tumors by a radiolabeled monoclonal antibody.Japanese journal of cancer research : Gann · 1997Article
- Cellular fibronectin concentration in the plasma of patients with malignant and benign diseases: a comparison with CA 19-9 and CEA.British journal of cancer · 1997Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vitro studies have demonstrated that fibronectin (FN) can deliver a mitogenic signal to quiescent human melanoma cells and that the alpha 5/beta 1-integrin receptor mediates this stimulus. In view of this finding we have analysed the in vivo expression of FN, and of ED-A and ED-B FN isoforms, in benign and malignant lesions of melanocyte origin. In the same specimens the expression of fibronectin integrin receptors was evaluated. The results demonstrate that, while detection of FN does not correlate with transformation and tumour progression, the expression of the two isoforms is associated with transformation and that only the ED-A variant is found in metastases. Integrin phenotyping disclosed that alpha 3/beta 1 expression is associated with tumour progression, alpha v/beta 3 is a marker of transformation, alpha 4 is rarely expressed and alpha 5 is expressed by about 50% and 30% of the primary and metastatic lesions respectively. Taken together, the results of this study demonstrate that transformation and tumour progression of the melanocyte lineage are associated with modulation of expression of FN isoforms and FN integrin receptors. Furthermore, the expression of alpha 5-integrin in a considerable percentage of primary and metastatic lesions indicates that FN may deliver a proliferative stimulus to melanoma cells in vivo.
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