ArticleThe American journal of pathology1995
Platelet-derived growth factor ligand and receptor expression by large vessel endothelium in vivo.
Article in The American journal of pathology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 68 citations in OpenAlex.
- Optimizing endothelial cell functionalization for cell therapy of vascular proliferative disease using a direct contact co-culture system.Drug delivery and translational research · 2018Article
- Discovery of High-Affinity PDGF-VEGFR Interactions: Redefining RTK Dynamics.Scientific reports · 2017Article
- Characterization of Pdgfrb-Cre transgenic mice reveals reduction of ROSA26 reporter activity in remodeling arteries.Genesis (New York, N.Y. : 2000) · 2011Article
- Scaffold-free in vitro arterial mimetics: the importance of smooth muscle-endothelium contact.Tissue engineering. Part A · 2010Article
- Molecular recognition elements: DNA/RNA-aptamers to proteins.Biochemistry (Moscow) Supplement. Series B, Biomedical chemistry · 2010Review
- PDGF-A promoter and enhancer elements provide efficient and selective antineoplastic gene therapy in multiple cancer types.Cancer gene therapy · 2009Article
- C-reactive protein and vein graft disease: evidence for a direct effect on smooth muscle cell phenotype via modulation of PDGF receptor-beta.American journal of physiology. Heart and circulatory physiology · 2008Article
- Endothelial injury induces vascular smooth muscle cell proliferation in highly localized regions of a direct contact co-culture system.Cell biochemistry and biophysics · 2008Article
- Peroxide-inducible Ets-1 mediates platelet-derived growth factor receptor-alpha gene transcription in vascular smooth muscle cells.The American journal of pathology · 2005Article
- Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors.The Journal of clinical investigation · 2005Article
- Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction.The American journal of pathology · 2001Article
- Early growth response factor-1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor-2.The American journal of pathology · 1999Article
- A quantitative method for determination of endothelial mRNA expression in vivo: induction of platelet-derived growth factor by endotoxin.The American journal of pathology · 1998Article
- Platelet-derived growth factor causes pulmonary cell proliferation and collagen deposition in vivo.The American journal of pathology · 1996Article
- Identification of platelet-derived growth factor A and B chains in human renal vascular rejection.The American journal of pathology · 1996Article
- Signals controlling the expression of PDGF.Molecular biology reportsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Using an injury model of the rat carotid artery and aorta, we have determined the time course of expression for PDGF ligands and receptors in endothelium by in situ hybridization and immunostaining. Platelet-derived growth factor (PDGF)-A and -B chains-were expressed in endothelial cells at the wound edge, but no expression was detectable in uninjured endothelium. PDGF-alpha receptor was expressed in a similar pattern as PDGF-A chain whereas expression of PDGF-beta receptor was not detected at any time. Expression of PDGF-B chain did not correlate with endothelial cell replication and a neutralizing antibody against PDGF-B had no effect on endothelial regrowth in the denuded aorta. Intimal smooth muscle cells are known to express PDGF-beta receptors and could thus be stimulated to migrate in response to PDGF-B from endothelial cells.
Indexed as
Identifiers
7778687PMC1870903W1534255397What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.