ArticleThe American journal of pathology1995
Tumor necrosis factor-alpha is expressed by glomerular visceral epithelial cells in human membranous nephropathy.
Article in The American journal of pathology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Renal manifestations in inflammatory bowel disease: a systematic review.Journal of gastroenterology · 2022Pooled it
- Pathogenesis of HIV-associated nephropathy in children and adolescents: taking a hard look 40 years later in the era of gene-environment interactions.American journal of physiology. Renal physiology · 2024Review
- Novel immune cross-talk between inflammatory bowel disease and IgA nephropathy.Renal failure · 2024Article
- Mechanism of action ofRenal failure · 2022Article
- Anti-Inflammatory, Anti-Apoptotic, and Antioxidant Roles of Honey, Royal Jelly, and Propolis in Suppressing Nephrotoxicity Induced by Doxorubicin in Male Albino Rats.Antioxidants (Basel, Switzerland) · 2022Article
- Role of the adaptive immune system in diabetic kidney disease.Journal of diabetes investigation · 2022Review
- Intrarenal Single-Cell Sequencing of Hepatitis B Virus Associated Membranous Nephropathy.Frontiers in medicine · 2022Article
- Renal involvement in paediatric inflammatory bowel disease.Pediatric nephrology (Berlin, Germany) · 2021Article
- Advances in Pathogenesis of Idiopathic Membranous Nephropathy.Kidney diseases (Basel, Switzerland) · 2020Review
- TNF-α in T lymphocytes attenuates renal injury and fibrosis during nephrotoxic nephritis.American journal of physiology. Renal physiology · 2020Article
- KLF4 in Macrophages Attenuates TNFJournal of the American Society of Nephrology : JASN · 2019Article
- [Extramembranous glomerulonephritis and myelodysplastic syndrome: a rare association].The Pan African medical journal · 2018Review
- Transmembrane TNF-Journal of the American Society of Nephrology : JASN · 2017Article
- Diabetes-Induced Reactive Oxygen Species: Mechanism of Their Generation and Role in Renal Injury.Journal of diabetes research · 2017Review
- Biologics for the treatment of autoimmune renal diseases.Nature reviews. Nephrology · 2016Review
- Circulating Tumor Necrosis Factor α Receptors Predict the Outcomes of Human IgA Nephropathy: A Prospective Cohort Study.PloS one · 2015Article
- Inflammatory processes in renal fibrosis.Nature reviews. Nephrology · 2014Review
- Immunopathogenesis of membranous nephropathy: an update.Seminars in immunopathology · 2014Review
- 4G/5G plasminogen activator inhibitor-1 and -308 A/G tumor necrosis factor-α promoter gene polymorphisms in Argentinean lupus patients: focus on lupus nephritis.Clinical and experimental medicine · 2014Article
- Tumor necrosis factor-α: regulation of renal function and blood pressure.American journal of physiology. Renal physiology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of tumor necrosis factor alpha (TNF-alpha) was examined in biopsy-proven glomerulonephritis by immunohistochemistry, in situ hybridization, immunogold electron microscopy, immunoassay in serum and urine, and urinary immunoblot. Striking glomerular capillary wall and visceral glomerular epithelial cell TNF-alpha protein staining was observed in all cases of membranous nephropathy and membranous lupus nephropathy. Staining was less frequently observed in crescentic glomerulonephritis and in isolated cases of other histological subtypes of glomerulonephritis, usually in association with glomerular macrophages. By immunogold electron microscopy TNF-alpha was localized in membranous nephropathy within the visceral glomerular epithelial cells, and also in the glomerular basement membrane, especially in relation to immune deposits. In situ hybridization localized TNF-alpha mRNA exclusively to glomerular epithelial cells in all biopsies with membranous morphology but not in other histological subtypes. Concentrations of TNF-alpha were significantly increased compared with normal controls in the urine of patients with membranous nephropathy and with crescentic glomerulonephritis. The expression of TNF-alpha by glomerular epithelial cells exclusively and universally in biopsies showing a membranous morphology strongly suggests this cytokine has a role in the pathogenesis of membranous nephropathy.
Indexed as
Identifiers
7778683PMC1870891W2164326564What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.