ArticleProceedings of the National Academy of Sciences of the United States of America1995
Multiple loci govern the bone marrow-derived immunoregulatory mechanism controlling dominant resistance to autoimmune orchitis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- A Comprehensive Bibliometric Analysis of Orchitis Research from 1980 to 2023.Advances in experimental medicine and biology · 2025Review
- Autoimmune experimental orchitis and chronic glomerulonephritis with end stage renal disease are controlled by Cgnz1 for susceptibility to end organ damage.Clinical immunology (Orlando, Fla.) · 2021Article
- Forward genetic approaches for elucidation of novel regulators of Lyme arthritis severity.Frontiers in cellular and infection microbiology · 2014Review
- Identification of Orch3, a locus controlling dominant resistance to autoimmune orchitis, as kinesin family member 1C.PLoS genetics · 2012Article
- A locus on chromosome 1 promotes susceptibility of experimental autoimmune myocarditis and lymphocyte cell death.Clinical immunology (Orlando, Fla.) · 2009Article
- Genetic complexity of autoimmune myocarditis.Autoimmunity reviews · 2008Review
- Genetic mapping of loci controlling diethylstilbestrol-induced thymic atrophy in the Brown Norway rat.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- Article
- Estrogen receptor-1 (Esr1) and -2 (Esr2) regulate the severity of clinical experimental allergic encephalomyelitis in male mice.The American journal of pathology · 2004Article
- Integrative genomics: in silico coupling of rat physiology and complex traits with mouse and human data.Genome research · 2004Article
- Susceptibility to anthrax lethal toxin is controlled by three linked quantitative trait loci.The American journal of pathology · 2003Article
- Sex-specific quantitative trait loci govern susceptibility to Theiler's murine encephalomyelitis virus-induced demyelination.Genetics · 2003Article
- Mapping of genes involved in murine herpes simplex virus keratitis: identification of genes and their modifiers.Journal of virology · 2002Article
- Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Autoimmune orchitis, epididymitis, and vasitis are immunogenetically distinct lesions.The American journal of pathology · 1998Article
- Evidence for the genetic control of estradiol-regulated responses. Implications for variation in normal and pathological hormone-dependent phenotypes.The American journal of pathology · 1997Article
- Aod2, the locus controlling development of atrophy in neonatal thymectomy-induced autoimmune ovarian dysgenesis, co-localizes with Il2, Fgfb, and Idd3.The Journal of experimental medicine · 1996Article
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Authors and funding
8 authors.
Funding
Abstract
The existence of immunoregulatory genes conferring dominant resistance to autoimmunity is well documented. In an effort to better understand the nature and mechanisms of action of these genes, we utilized the murine model of autoimmune orchitis as a prototype. When the orchitis-resistant strain DBA/2J is crossed with the orchitis-susceptible strain BALB/cByJ, the F1 hybrid is completely resistant to the disease. By using reciprocal radiation bone marrow chimeras, the functional component mediating this resistance was mapped to the bone marrow-derived compartment. Resistance is not a function of either low-dose irradiation- or cyclophosphamide (20 mg/kg)-sensitive immunoregulatory cells, but can be adoptively transferred by primed splenocytes. Genome exclusion mapping identified three loci controlling the resistant phenotype. Orch3 maps to chromosome 11, whereas Orch4 and Orch5 map to the telomeric and centromeric regions of chromosome 1, respectively. All three genes are linked to a number of immunologically relevant candidate loci. Most significant, however, is the linkage of Orch3 to Idd4 and Orch5 to Idd5, two susceptibility genes which play a role in autoimmune insulin-dependent type 1 diabetes mellitus in the nonobese diabetic mouse.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.