ArticleProceedings of the National Academy of Sciences of the United States of America1995
Human immunodeficiency virus 1 reservoir in CD4+ T cells is restricted to certain V beta subsets.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- T cell receptor usage in patients with non-progressing HIV infection.Clinical and experimental immunology · 2002Article
- Productive infection of double-negative T cells with HIV in vivo.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Early increase of CD4+ CD45RA+ and CD4+ CD95- cells with conserved repertoire induced by anti-retroviral therapy in HIV-infected patients.Clinical and experimental immunology · 1998Article
- Enhancement of feline immunodeficiency virus (FIV) infection after DNA vaccination with the FIV envelope.Journal of virology · 1997Article
- TCR binding differs for a bacterial superantigen (SEE) and a viral superantigen (Mtv-9).The Journal of experimental medicine · 1996Article
- Virus-encoded superantigens.Microbiological reviews · 1996Review
- Study of the T cell receptor repertoire in viral immunodeficiency disease.Springer seminars in immunopathology · 1996Review
- Superantigens related to B cell hyperplasia.Springer seminars in immunopathology · 1996Review
- The HIV-1 reservoir in distinct V beta subsets of CD4 T cells: evidence for a putative superantigen.Journal of clinical immunology · 1995Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The human immunodeficiency virus 1 (HIV-1) replicates more efficiently in T-cell lines expressing T-cell receptors derived from certain V beta genes, V beta 12 in particular, suggesting the effects of a superantigen. The targeted V beta 12 subset was not deleted in HIV-1-infected patients. It was therefore possible that it might represent an in vivo viral reservoir. Viral load was assessed by quantitative PCR with gag primers and with an infectivity assay to measure competent virus. It was shown that the tiny V beta 12 subset (1-2% of T cells) often has a higher viral load than other V beta subsets in infected patients. Selective HIV-1 replication in V beta 12 cells was also observed 6-8 days after in vitro infection of peripheral blood lymphocytes from normal, HIV-1 negative donors. Viral replication in targeted V beta subsets may serve to promote a biologically relevant viral reservoir.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.