ArticleProceedings of the National Academy of Sciences of the United States of America1995
Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 191 citations in OpenAlex.
- Function-driven design of a surrogate interleukin-2 receptor ligand.FEBS letters · 2026Article
- JAK/STAT: Why choose a classical or an alternative pathway when you can have both?Journal of cellular and molecular medicine · 2022Review
- Regulatory T cells engineered with TCR signaling-responsive IL-2 nanogels suppress alloimmunity in sites of antigen encounter.Science translational medicine · 2020Article
- Staphylococcus aureus enterotoxins induce FOXP3 in neoplastic T cells in Sézary syndrome.Blood cancer journal · 2020Article
- Defining the Threshold IL-2 Signal Required for Induction of Selective Treg Cell Responses Using Engineered IL-2 Muteins.Frontiers in immunology · 2020Article
- Genome wide association study identifies novel potential candidate genes for bovine milk cholesterol content.Scientific reports · 2018Article
- A critical role of the Thy28-MYH9 axis in B cell-specific expression of the Pax5 gene in chicken B cells.PloS one · 2015Article
- Article
- Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction.Biochemical and biophysical research communications · 2007Article
- Cytokine signaling to the cell cycle.Immunologic research · 2007Review
- Lack of phosphotyrosine phosphatase SHP-1 expression in malignant T-cell lymphoma cells results from methylation of the SHP-1 promoter.The American journal of pathology · 2000Article
- Differential requirement of the cytoplasmic subregions of gamma c chain in T cell development and function.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Review
- The role of STAT proteins in growth hormone signaling.Oncogene · 2000Review
- A small amphipathic alpha-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5.The EMBO journal · 2000Article
- Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation.Genes & development · 2000Article
- IL-3 dependent regulation of Bcl-xL gene expression by STAT5 in a bone marrow derived cell line.Oncogene · 1999Article
- Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling.The EMBO journal · 1999Article
- The significance of tetramerization in promoter recruitment by Stat5.Molecular and cellular biology · 1999Article
- Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells.The EMBO journal · 1999Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The high-affinity interleukin 2 (IL-2) receptor (IL-2R) consists of three subunits: the IL-2R alpha, IL-2R beta c, and IL-2R gamma c chains. Two members of the Janus kinase family, Jak1 and Jak3, are associated with IL-2R beta c and IL-2R gamma c, respectively, and they are activated upon IL-2 stimulation. The cytokine-mediated Jak kinase activation usually results in the activation of a family of latent transcription factors termed Stat (signal transducer and activator of transcription) proteins. Recently, the IL-2-induced Stat protein was purified from human lymphocytes and found to be the homologue of sheep Stat5/mammary gland factor. We demonstrate that the human Stat5 is activated by IL-2 and that Jak3 is required for the efficient activation. The cytoplasmic region of the IL-2R beta c chain required for activation of Stat5 is mapped within the carboxyl-terminal 147 amino acids. On the other hand, this region is not essential for IL-2-induced cell proliferation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.