ArticleProceedings of the National Academy of Sciences of the United States of America1995
Inhibition of human immunodeficiency virus replication by nonimmunosuppressive analogs of cyclosporin A.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 72 citations in OpenAlex.
- The Role of Cyclophilins in Inflammatory Bowel Disease and Colorectal Cancer.International journal of biological sciences · 2021Review
- Article
- Correlation of naturally occurring HIV-1 resistance to DEB025 with capsid amino acid polymorphisms.Viruses · 2013Article
- Liver transplantation in HCV/HIV positive patients.World journal of gastrointestinal surgery · 2011Article
- Article
- Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent.Antimicrobial agents and chemotherapy · 2008Article
- Analysis of human cell heterokaryons demonstrates that target cell restriction of cyclosporine-resistant human immunodeficiency virus type 1 mutants is genetically dominant.Journal of virology · 2007Article
- Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells.Journal of virology · 2005Article
- The use of two immunosuppressive drugs, cyclosporin A and tacrolimus, to inhibit virus replication and apoptosis in cells infected with feline immunodeficiency virus.Veterinary research communications · 1998Article
- Human immunodeficiency virus type 1 replication is modulated by host cyclophilin A expression levels.Journal of virology · 1998Article
- Cyclosporin analogs inhibit in vitro growth of Cryptosporidium parvum.Antimicrobial agents and chemotherapy · 1998Article
- Role of cyclophilin A in the uptake of HIV-1 by macrophages and T lymphocytes.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Cells with high cyclophilin A content support replication of human immunodeficiency virus type 1 Gag mutants with decreased ability to incorporate cyclophilin A.Journal of virology · 1998Article
- Transfer of the HIV-1 cyclophilin-binding site to simian immunodeficiency virus from Macaca mulatta can confer both cyclosporin sensitivity and cyclosporin dependence.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Active-site residues of cyclophilin A are crucial for its incorporation into human immunodeficiency virus type 1 virions.Journal of virology · 1997Article
- The hydrophobic pocket of cyclophilin is the binding site for the human immunodeficiency virus type 1 Gag polyprotein.Journal of virology · 1997Article
- Functional gamma delta T-lymphocyte defect associated with human immunodeficiency virus infections.Molecular medicine (Cambridge, Mass.) · 1997Article
- The human immunodeficiency virus type 1 capsid p2 domain confers sensitivity to the cyclophilin-binding drug SDZ NIM 811.Journal of virology · 1996Article
- Cyclosporine A-resistant human immunodeficiency virus type 1 mutants demonstrate that Gag encodes the functional target of cyclophilin A.Journal of virology · 1996Article
- Binding of the human immunodeficiency virus type 1 Gag polyprotein to cyclophilin A is mediated by the central region of capsid and requires Gag dimerization.Journal of virology · 1996Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Analogs of the immunosuppressive cyclic undecapeptide cyclosporin A (CsA) with substitutions in positions 1, 4, 6, and/or 11 were rationally designed to possess substantially diminished or no immunosuppressive activity. When these compounds were assayed for their capacity to interfere with the replication of human immunodeficiency virus, some displayed a potent antiviral activity in newly infected cells. However, only CsA could interfere with virus replication in persistently infected cells. One CsA analog with antiviral activity costimulated the phytohemagglutinin-induced production of interleukin 2 by human lymphocytes. Human immunodeficiency virus particles from drug-exposed cells showed lower infectivity than virions from untreated cells. Thus, these nonimmunosuppressive analogs of CsA constitute a promising class of lead compounds to develop drugs for effective treatment of the acquired immunodeficiency syndrome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.