ArticleProceedings of the National Academy of Sciences of the United States of America1995
Position-dependent variegation of globin transgene expression in mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 159 citations in OpenAlex.
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- Gene Therapy for Cystic Fibrosis: Progress and Challenges of Genome Editing.International journal of molecular sciences · 2020Review
- The goat β‑casein/CMV chimeric promoter drives the expression of hLF in transgenic goats produced by cell transgene microinjection.International journal of molecular medicine · 2019Article
- Delivering on the promise of gene editing for cystic fibrosis.Genes & diseases · 2019Review
- Considerations for the use of Cre recombinase for conditional gene deletion in the mouse lens.Human genomics · 2019Article
- Molecular tools to create new strains for mosquito sexing and vector control.Parasites & vectors · 2018Review
- Production of functional human CuZn-SOD and EC-SOD in bitransgenic cloned goat milk.Transgenic research · 2018Article
- Expression of recombinant human lysozyme in transgenic chicken promotes the growth of Bifidobacterium in the intestine and improves postnatal growth of chicken.AMB Express · 2016Article
- Dual-Reporter β-Cell-Specific Male Transgenic Rats for the Analysis of β-Cell Functional Mass and Enrichment by Flow Cytometry.Endocrinology · 2016Article
- Aquaporin 2-labeled cells differentiate to intercalated cells in response to potassium depletion.Histochemistry and cell biology · 2016Article
- Expression of KRASG12V in Zebrafish Gills Induces Hyperplasia and CXCL8-Associated Inflammation.Zebrafish · 2015Article
- Generation of transgenic mouse fluorescent reporter lines for studying hematopoietic development.Methods in molecular biology (Clifton, N.J.) · 2014Article
- The use of mouse models to study epigenetics.Cold Spring Harbor perspectives in biology · 2013Review
- Human extracellular superoxide dismutase (EC-SOD) expression in transgenic chicken.BMB reports · 2013Article
- Conditional gene expression systems in the transgenic rat brain.BMC biology · 2012Article
- High-level transgene expression by homologous recombination-mediated gene transfer.Nucleic acids research · 2011Article
- Transgenerational analysis of transcriptional silencing in zebrafish.Developmental biology · 2011Article
- Transgene expression and transgene-induced silencing in diploid and autotetraploid Arabidopsis.Genetics · 2011Article
- DNA methylation in zebrafish.Progress in molecular biology and translational science · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expression of genes in eukaryotes has commonly been analyzed in a whole tissue, and levels of expression have been interpreted as the result of equivalent rates of transcription in every cell. We have produced transgenic mouse lines that express beta-galactosidase under the control of globin promoters linked to the major tissue-specific regulatory element of the alpha-globin locus, which permits the analysis of transgene expression in individual red blood cells. We find that expression of the transgene within all mouse lines is heterocellular. Individual cells either do not express the transgene at all or express it at a level characteristic of that line. The number of beta-galactosidase-expressing cells varies greatly between different lines of transgenic mice at any defined stage of development, but within a transgenic line, individual mice have strikingly similar numbers of expressing cells. This suggests that the degree of heterocellular expression is determined by the site of integration, as is seen in position-effect variegation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.