ArticleProceedings of the National Academy of Sciences of the United States of America1995
Efficient high-resolution genetic mapping of mouse interspersed repetitive sequence PCR products, toward integrated genetic and physical mapping of the mouse genome.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Single-Cell Genomic Analysis in Plants.Genes · 2018Review
- Expression and fine mapping of murine vasoactive intestinal peptide receptor 1.Journal of molecular neuroscience : MN · 2001Article
- Interspersed repetitive sequence (IRS)-PCR for typing of whole genome radiation hybrid panels.Nucleic acids research · 2000Article
- Development of the arbitrarily primed-representational difference analysis method and chromosomal mapping of isolated high throughput rat genetic markers.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Identification of novel simple sequence length polymorphisms (SSLPs) in mouse by interspersed repetitive element (IRE)-PCR.Nucleic acids research · 1998Article
- Characterization of an abundant short interspersed nuclear element (SINE) present in Canis familiaris.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
- IRS-PCR-based genetic mapping of the huntingtin interacting protein gene (HIP1) on mouse chromosome 5.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
- Simplified handling of high-density genetic filters using rigid plastic laminates.Nucleic acids research · 1997Article
- Genetic mapping of 18S ribosomal RNA-related loci to mouse chromosomes 5, 6, 9, 12, 17, 18, 19, and X.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- Genetic and physical mapping of the mouse Ulnaless locus.Genetics · 1996Article
- Generation and mapping of Mus spretus strain-specific markers for rapid genomic scanning.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- A rat genetic map constructed by representational difference analysis markers with suitability for large-scale typing.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
The ability to carry out high-resolution genetic mapping at high throughput in the mouse is a critical rate-limiting step in the generation of genetically anchored contigs in physical mapping projects and the mapping of genetic loci for complex traits. To address this need, we have developed an efficient, high-resolution, large-scale genome mapping system. This system is based on the identification of polymorphic DNA sites between mouse strains by using interspersed repetitive sequence (IRS) PCR. Individual cloned IRS PCR products are hybridized to a DNA array of IRS PCR products derived from the DNA of individual mice segregating DNA sequences from the two parent strains. Since gel electrophoresis is not required, large numbers of samples can be genotyped in parallel. By using this approach, we have mapped > 450 polymorphic probes with filters containing the DNA of up to 517 backcross mice, potentially allowing resolution of 0.14 centimorgan. This approach also carries the potential for a high degree of efficiency in the integration of physical and genetic maps, since pooled DNAs representing libraries of yeast artificial chromosomes or other physical representations of the mouse genome can be addressed by hybridization of filter representations of the IRS PCR products of such libraries.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.