ArticleProceedings of the National Academy of Sciences of the United States of America1995
Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 179 citations in OpenAlex.
- The role of PALLD-STAT3 interaction in megakaryocyte differentiation and thrombocytopenia treatment.Haematologica · 2024Article
- In and out: Traffic and dynamics of thrombopoietin receptor.Journal of cellular and molecular medicine · 2021Review
- Reprogramming signal transduction through a designer receptor tyrosine kinase.Communications biology · 2021Article
- Cytokine receptor splice variants in hematologic diseases.Cytokine · 2020Review
- Dissection of Signaling Events Downstream of the c-Mpl Receptor in Murine Hematopoietic Stem Cells Via Motif-Engineered Chimeric Receptors.Stem cell reviews and reports · 2018Article
- Estrogen promotes megakaryocyte polyploidization via estrogen receptor beta-mediated transcription of GATA1.Leukemia · 2017Article
- The Thrombopoietin Receptor: Structural Basis of Traffic and Activation by Ligand, Mutations, Agonists, and Mutated Calreticulin.Frontiers in endocrinology · 2017Review
- Article
- RNA-seq based transcriptome analysis of hepatitis E virus (HEV) and hepatitis B virus (HBV) replicon transfected Huh-7 cells.PloS one · 2014Article
- Eltrombopag inhibition of acute myeloid leukemia cell survival does not depend on c-Mpl expression.Leukemia · 2013Article
- Orientation-specific signalling by thrombopoietin receptor dimers.The EMBO journal · 2011Article
- New advances in the treatment of adult chronic immune thrombocytopenic purpura: role of thrombopoietin receptor-stimulating agents.Biologics : targets & therapy · 2009Article
- Pathobiology of secondary immune thrombocytopenia.Seminars in hematology · 2009Review
- Human thrombopoietin reduces myocardial infarct size, apoptosis, and stunning following ischaemia/reperfusion in rats.Cardiovascular research · 2008Article
- Signals emanating from the membrane proximal region of the thrombopoietin receptor (mpl) support hematopoietic stem cell self-renewal.Experimental hematology · 2007Article
- New thrombopoietic growth factors.Blood · 2007Review
- Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses.Immunology · 2004Review
- Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Molecular control of megakaryopoiesis and thrombopoiesis.International journal of hematology · 2002Review
- Dissection of the cytoplasmic domains of cytokine receptors involved in STAT and Ras dependent proliferation.Oncogene · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
c-Mpl, a member of the hematopoietic cytokine receptor family, is the receptor for thrombopoietin. To investigate signal transduction by c-Mpl, a chimeric receptor, composed of the extracellular domain of human growth hormone receptor and the intracellular domain of c-Mpl, was introduced into the interleukin 3-dependent cell line Ba/F3. In response to growth hormone, this chimeric receptor induced growth in the absence of interleukin 3. Deletion analysis of the 123-amino acid intracellular domain indicated that the elements responsible for this effect are present within the 63 amino acids proximal to the transmembrane domain. Mutation of the recently described box 1 motif abrogated the proliferative response. Tyrosine phosphorylation of the tyrosine kinase JAK-2 and activation of STAT proteins were dependent on box 1 and sequences within 63 amino acids of the plasma membrane. STAT proteins activated by thrombopoietin in a megakaryocytic cell line were purified and shown to be STAT1 and STAT3. A separate region located at the C terminus of the c-Mpl intracellular domain was found to be required for induction of Shc phosphorylation and c-fos mRNA accumulation, suggesting involvement of the Ras signal transduction pathway. Thus, at least two distinct regions are involved in signal transduction by the c-Mpl.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.