ArticleImmunologic research1994
Structural properties of a subset of nephritogenic anti-DNA antibodies.
Article in Immunologic research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Deciphering evolution of immune recognition in antibodies.BMC structural biology · 2018Article
- Molecular and Immunological Basis of Tubulo-Interstitial Injury in Lupus Nephritis: a Comprehensive Review.Clinical reviews in allergy & immunology · 2017Review
- Anti-nuclear antibody reactivity in lupus may be partly hard-wired into the primary B-cell repertoire.Molecular immunology · 2009Article
- Molecular hallmarks of anti-chromatin antibodies associated with the lupus susceptibility locus, Sle1.Molecular immunology · 2009Article
- Pathogenic profiles and molecular signatures of antinuclear autoantibodies rescued from NZM2410 lupus mice.The Journal of experimental medicine · 2004Article
- The antigenic properties of bacterial DNA in normal and aberrant immunity.Springer seminars in immunopathology · 2000Review
- T cells of lupus and molecular targets for immunotherapy.Journal of clinical immunology · 1997Review
- Mechanisms of the pathogenic autoimmune response in lupus: prospects for specific immunotherapy.Immunologic research · 1995Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Structural analysis of lupus autoantibodies is beginning to provide clues to the molecular basis for antigenic specificity and pathogenicity. The present analysis indicates that multiple light and heavy chains contain residues which can facilitate DNA binding, reaffirming the notion that there are multiple ways that different amino acids combine to form an antigen-binding pocket with affinity for dsDNA and ssDNA. Furthermore, this analysis suggests that these conformations and contact residues are intrinsic to germline sequences, although amino acid changes at critical locations (somatically introduced) modulate antigen binding, and appear to influence the capacity of individual immunoglobulin to form immune deposits. Analysis of additional individual immunoglobulins with closely related V-region sequences and differing pathogenic properties will be required to resolve the contribution of specific motifs to pathogenecity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.