ArticleJapanese journal of cancer research : Gann1995
Frequent genetic instability in small intestinal carcinomas.
Article in Japanese journal of cancer research : Gann, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Concurrent loss of MLH1, PMS2 and MSH6 immunoexpression in digestive system cancers indicating a widespread dysregulation in DNA repair processes.Frontiers in oncology · 2022Article
- Immunophenotype and molecular characterisation of adenocarcinoma of the small intestine.British journal of cancer · 2010Article
- Immunohistochemical analysis of adenocarcinoma of the small intestine: a tissue microarray study.Journal of clinical pathology · 2003Article
- Article
- Combination analysis of genetic alterations and cell proliferation in small intestinal carcinomas.Digestive diseases and sciences · 2000Article
- Alternative splicing of the FHIT gene in colorectal cancers.Japanese journal of cancer research : Gann · 1997Article
- Loss of heterozygosity of microsatellite loci on chromosome 9p in astrocytic tumors and its prognostic implications.Journal of neuro-oncology · 1996Article
- Midgut Carcinoids and Solid Carcinomas of the Intestine: Differences in Endocrine Markers and p53 Mutations.Endocrine pathology · 1996Article
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5 authors.
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Abstract
To determine whether genetic instability plays a part in the development of digestive tract carcinomas, we analyzed 3 microsatellite loci isolated from tumors and surrounding normal tissue samples obtained during surgery. The polymerase chain reaction (PCR) technique was used to assess differences between tumor and matched normal DNAs. Replication errors (RERs) were observed in 3 of the 29 cases (10%) of gastric carcinoma and in 11 of the 72 cases (15%) of colorectal carcinoma. None of the 13 (0%) esophageal carcinoma cases showed any RER, but 5 of the 11 cases of small intestinal carcinoma (45%) had RERs, a significantly frequent finding. These results suggest that genetic instability plays an important role in the pathogenesis of small intestinal carcinomas.
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