ArticleClinical and experimental immunology1995
Occurrence of disseminated intravascular coagulation (DIC) in active systemic anaphylaxis: role of platelet-activating factor.
Article in Clinical and experimental immunology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 51 citations in OpenAlex.
- Anaphylaxis and Severe Disseminated Intravascular Coagulation Due to Remdesivir.Internal medicine (Tokyo, Japan) · 2024Article
- Fatal Allergic Reaction to Gadolinium Contrast.Cureus · 2023Article
- Allergy, inflammation, hepatopathy and coagulation biomarkers in dogs with suspected anaphylaxis due to insect envenomation.Frontiers in veterinary science · 2022Article
- Mechanisms Governing Anaphylaxis: Inflammatory Cells, Mediators, Endothelial Gap Junctions and Beyond.International journal of molecular sciences · 2021Review
- The Mast Cell, Contact, and Coagulation System Connection in Anaphylaxis.Frontiers in immunology · 2017Review
- Article
- Allergy and the cardiovascular system.Clinical and experimental immunology · 2008Review
- Selective involvement of reactive oxygen intermediates in platelet-activating factor-mediated activation of NF-kappaB.Inflammation · 2000Article
- Immunoglobulin E-dependent active fatal anaphylaxis in mast cell-deficient mice.The Journal of experimental medicine · 1998Article
- A protective role of platelet-activating factor in murine candidiasis.Infection and immunity · 1997Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The possible occurrence of DIC in active systemic anaphylaxis was investigated in mice. Induction of active systemic anaphylaxis resulted in the development of DIC symptoms such as thrombocytopenia, prolongation of prothrombin time, hypofibrinogaemia, and elevated level of fibrinogen/fibrin degradation products. In addition, in histological examinations, massive congestion and cellular infiltration in pulmonary interstitia, and considerable haemorrhage in renal medullae were observed. All these changes were nearly completely prevented by pretreatment with platelet-activating factor (PAF) antagonist (BN 50739). Moreover, the same haematological and morphological changes were produced by a bolus injection of PAF. These data strongly suggest that DIC occurs in active systemic anaphylaxis and PAF plays a pivotal role in the development of DIC in anaphylaxis.
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Registered trials
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