ArticleParasitology research1995
Suppression of murine lymphocyte proliferation induced by a small RNA purified from the Taenia solium metacestode.
Article in Parasitology research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 36 citations in OpenAlex.
- Cellular and molecular basis associated with metacestode proliferation in subarachnoid neurocysticercosis.Frontiers in immunology · 2022Article
- Regulatory T Cells as an Escape Mechanism to the Immune Response inFrontiers in cellular and infection microbiology · 2021Article
- Granulomas in parasitic diseases: the good and the bad.Parasitology research · 2020Review
- MicroRNAs inFrontiers in microbiology · 2017Review
- The implantation of Taenia solium metacestodes in mice induces down-modulation of T-cell proliferation and cytokine production.Parasitology research · 2005Article
- A cysteine protease from Taenia solium metacestodes induce apoptosis in human CD4+ T-cells.Parasitology research · 2004Article
- Antigen-specific suppression of cultured lymphocytes from patients with neurocysticercosis.Clinical and experimental immunology · 2001Article
- Granuloma cytokines in murine cysticercosis.Infection and immunity · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A substance from Taenia solium metacestodes that decreases lymphocyte proliferation induced by concanavalin A was isolated. The molecular weight of this substance was estimated to be slightly more than 1,450 Da. Crude metacestode factor was fractionated through a Bio-gel P-6 column. Peak 1 showed suppressive activity. After incubation with RNase the substance lost its activity. Incubation of this material with trypsin or papain increased its suppressive activity. It was stable at boiling temperature for 10 min. The incubation of this substance with murine macrophages had no effect on [3H]-thymidine uptake by cocultured fresh splenic lymphocytes stimulated with concanavalin A. Conversely, cocultures of lymphocytes pretreated with the substance and fresh splenic lymphocytes showed a decreased incorporation of [3H]-thymidine. These results suggest that this substance is a RNA-peptide molecule whose RNA moiety accounts for its suppressive activity. The findings also suggest that in vivo the factor may be a modulator of the immune response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.