ArticleNaunyn-Schmiedeberg's archives of pharmacology1995
Inhibition by suramin and reactive blue 2 of GABA and glutamate receptor channels in rat hippocampal neurons.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Regulation of GABAergic neurotransmission by purinergic receptors in brain physiology and disease.Purinergic signalling · 2025Review
- 100 Years of Suramin.Antimicrobial agents and chemotherapy · 2020Review
- Suppression of cell membrane permeability by suramin: involvement of its inhibitory actions on connexin 43 hemichannels.British journal of pharmacology · 2014Article
- Potentiation of inhibitory synaptic transmission by extracellular ATP in rat suprachiasmatic nuclei.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Interaction of medullary P2 and glutamate receptors mediates the vasodilation in the hindlimb of rat.Purinergic signalling · 2012Article
- P2X purinoceptors mediate an endothelium-dependent hyperpolarization in longitudinal smooth muscle of anterior mesenteric artery in young chickens.British journal of pharmacology · 2009Article
- Purinergic type 2 receptors at GABAergic synapses on ventral tegmental area dopamine neurons are targets for ethanol action.The Journal of pharmacology and experimental therapeutics · 2008Article
- Role of P2 purinergic receptors in synaptic transmission under normoxic and ischaemic conditions in the CA1 region of rat hippocampal slices.Purinergic signalling · 2007Article
- P2 receptors are involved in the mediation of motivation-related behavior.Purinergic signalling · 2004Article
- Purinergic signalling in the medullary mechanisms of respiratory control in the rat: respiratory neurones express the P2X2 receptor subunit.The Journal of physiology · 2003Article
- Fast synaptic transmission mediated by P2X receptors in CA3 pyramidal cells of rat hippocampal slice cultures.The Journal of physiology · 2001Article
- ATP facilitates spontaneous glycinergic IPSC frequency at dissociated rat dorsal horn interneuron synapses.The Journal of physiology · 2000Article
- Synaptic control of motoneuronal excitability.Physiological reviews · 2000Review
- Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice.British journal of pharmacology · 1999Article
- Central CO2 chemoreception: a mechanism involving P2 purinoceptors localized in the ventrolateral medulla of the anaesthetized rat.The Journal of physiology · 1999Article
- Inhibition by ATP of hippocampal synaptic transmission requires localized extracellular catabolism by ecto-nucleotidases into adenosine and channeling to adenosine A1 receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Review
- P2 receptor excitation of rodent hypoglossal motoneuron activity in vitro and in vivo: a molecular physiological analysis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- New insights on P2X purinoceptors.Naunyn-Schmiedeberg's archives of pharmacology · 1995Review
- Electrophysiological analysis of the actions of pituitary adenylyl cyclase activating peptide in the taenia of the guinea-pig caecum.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effects of suramin and reactive blue 2 (RB2), compounds known as antagonists at P2-purinoceptors, on ionic currents mediated through GABA and glutamate receptor channels were investigated in rat hippocampal neurons. Under whole-cell voltage-clamp, suramin (30 to 300 microM) and RB2 (10 to 100 microM) inhibited a current activated by 10 microM GABA in a concentration-dependent manner. Suramin (100 and 300 microM) and RB2 (10 and 30 microM) also inhibited an inward current activated by kainic acid (100 microM), an agonist at non-NMDA type glutamate receptor channels, and an inward current activated by N-methyl-D-aspartate (NMDA; 100 microM), an agonist at NMDA type glutamate receptor channels. The inhibition by suramin or RB2 did not exhibit voltage-dependence between -30 and -90 mV in the case of the GABA- or the kainate-evoked current. In contrast, the inhibition by these compounds of the NMDA-evoked current exhibited voltage-dependence and was enhanced by hyperpolarization. When the concentration of agonists was increased by 5- or 10-fold, the magnitude of the inhibition by suramin of the kainate-evoked current and the magnitude of the inhibition by RB2 of the NMDA-evoked current were attenuated. alpha,beta-Methylene ATP (100 microM) did not affect the GABA-, kainate- or NMDA-activated current. The results suggest that suramin and RB2 inhibit GABA receptor channels and glutamate receptor channels. The blockade of these channels must be taken into account when these compounds are used as pharmacological tools to examine an involvement of P2-purinoceptors, especially in preparations where GABAergic or glutamatergic neurotransmission is expected.
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