ArticleThe Journal of clinical investigation1995
Mast cells and histamine contribute to bile acid-stimulated secretion in the mouse colon.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 75 citations in OpenAlex.
- Loss of apical sodium bile acid transporter alters bile acid circulation and reduces biliary damage in cholangitis.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- Contributions of bile acids to gastrointestinal physiology as receptor agonists and modifiers of ion channels.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
- Mast Cells Regulate Ductular Reaction and Intestinal Inflammation in Cholestasis Through Farnesoid X Receptor Signaling.Hepatology (Baltimore, Md.) · 2021Article
- Role of gut microbiota in functional constipation.Gastroenterology report · 2021Review
- Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases.Frontiers in medicine · 2020Review
- The Effect of Deoxycholic Acid on Secretion and Motility in the Rat and Guinea Pig Large Intestine.Journal of neurogastroenterology and motility · 2017Article
- The Farnesoid X Receptor: Good for BAD.Cellular and molecular gastroenterology and hepatology · 2016Review
- Characterization of AQPs in Mouse, Rat, and Human Colon and Their Selective Regulation by Bile Acids.Frontiers in nutrition · 2016Article
- Secretory diarrhoea: mechanisms and emerging therapies.Nature reviews. Gastroenterology & hepatology · 2015Review
- Chenodeoxycholic acid stimulates Cl(-) secretion via cAMP signaling and increases cystic fibrosis transmembrane conductance regulator phosphorylation in T84 cells.American journal of physiology. Cell physiology · 2013Article
- Ursodeoxycholic acid attenuates colonic epithelial secretory function.The Journal of physiology · 2013Article
- Article
- Histamine regulation of hyperplastic and neoplastic cell growth in cholangiocytes.World journal of gastrointestinal pathophysiology · 2010Article
- Bile acids in regulation of intestinal physiology.Current gastroenterology reports · 2009Review
- Physiological concentrations of bile acids down-regulate agonist induced secretion in colonic epithelial cells.Journal of cellular and molecular medicine · 2009Article
- Intestinal bile acid physiology and pathophysiology.World journal of gastroenterology · 2008Review
- The effect of biliary sphincterotomy on serum cholesterol level in postcholecystectomy patients: a pilot study.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2007Article
- Systemic phosphatidylcholine pretreatment protects canine esophageal mucosa during acute experimental biliary reflux.World journal of gastroenterology · 2006Article
- Bile salt diarrhea.Current gastroenterology reports · 2005Review
- Esophageal visceral sensitivity to bile salts in patients with functional heartburn and in healthy control subjects.Digestive diseases and sciences · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Certain dihydroxy bile acids cause secretory diarrhea when present in the colonic lumen at inappropriately high concentrations. However, the mechanism underlying the secretagogue activity has not been fully elucidated. Experiments were performed to test whether mast cells and one of their major mediators, histamine, might contribute to the secretory effect. Chenodeoxycholic acid, a secretory bile acid, and ursodeoxycholic acid, a nonsecretory, hydrophilic bile acid, were compared for their ability to induce chloride secretion across segments of mouse colon mounted in Ussing chambers. Chenodeoxycholic acid, but not ursodeoxycholic acid, induced dose-dependent, biphasic chloride secretion that was greater after serosal than mucosal addition and was greater in distal versus proximal colonic segments. The secretory effect of chenodeoxycholic acid was inhibited by H1 histamine receptor antagonists and modified by the cyclooxygenase inhibitor indomethacin. However, it was unaffected by an H2 histamine receptor antagonist or by atropine. Secretory effects of chenodeoxycholic acid were diminished in magnitude and delayed in colonic tissues from mice with a genetic deficiency of tissue mast cells. Concentrations of chenodeoxycholic acid inducing secretion also released histamine from tissue segments. These data indicate that mast cells and histamine-mediated processes contribute significantly to the secretory effects of dihydroxy bile acids in the murine colon.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.