ArticleThe Journal of clinical investigation1995
Surfactant protein D interacts with Pneumocystis carinii and mediates organism adherence to alveolar macrophages.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 165 citations in OpenAlex.
- Immune Responses toJournal of inflammation research · 2026Review
- Current State of Carbohydrate Recognition and C-Type Lectin Receptors inFrontiers in immunology · 2021Review
- MUC1 mediates Pneumocystis murina binding to airway epithelial cells.Cellular microbiology · 2020Article
- Surfactant Protein D Recognizes Multiple Fungal Ligands: A Key Step to Initiate and Intensify the Anti-fungal Host Defense.Frontiers in cellular and infection microbiology · 2020Review
- Collectins: Innate Immune Pattern Recognition Molecules.Advances in experimental medicine and biology · 2020Review
- Is the unique camouflage strategy of Pneumocystis associated with its particular niche within host lungs?PLoS pathogens · 2019Review
- The Interaction of Human Pathogenic Fungi With C-Type Lectin Receptors.Frontiers in immunology · 2018Review
- Role of Soluble Innate Effector Molecules in Pulmonary Defense against Fungal Pathogens.Frontiers in microbiology · 2017Review
- Evidence for Proinflammatory β-1,6 Glucans in the Pneumocystis carinii Cell Wall.Infection and immunity · 2015Article
- Surfactant Protein D Binds to Coxiella burnetii and Results in a Decrease in Interactions with Murine Alveolar Macrophages.PloS one · 2015Article
- An Insight into the Diverse Roles of Surfactant Proteins, SP-A and SP-D in Innate and Adaptive Immunity.Frontiers in immunology · 2012Article
- Implications of the innate immune response to adenovirus and adenoviral vectors.Future virology · 2011Article
- Current understanding of Pneumocystis immunology.Future microbiology · 2010Review
- Characterization of a novel ADAM protease expressed by Pneumocystis carinii.Infection and immunity · 2009Article
- Cross-talk between pulmonary injury, oxidant stress, and gap junctional communication.Antioxidants & redox signaling · 2009Review
- Surfactant protein D is expressed and modulates inflammatory responses in human coronary artery smooth muscle cells.American journal of physiology. Heart and circulatory physiology · 2008Article
- Pneumocystis carinii exhibits a conserved meiotic control pathway.Infection and immunity · 2008Article
- The immunology of parasite infections in immunocompromised hosts.Parasite immunology · 2006Review
- Effect of lung surfactant collectins on bronchoalveolar macrophage interaction with Blastomyces dermatitidis: inhibition of tumor necrosis factor alpha production by surfactant protein D.Infection and immunity · 2006Article
- Noncapsulated Klebsiella pneumoniae bearing mannose-containing O antigens is rapidly eradicated from mouse lung and triggers cytokine production by macrophages following opsonization with surfactant protein D.Infection and immunity · 2005Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Pneumocystis carinii interacts with glycoproteins present in the lower respiratory tract through its mannose-rich surface antigen complex termed gpA. Surfactant protein D (SP-D) is a recently described component of the airspace lining material that possesses a calcium-dependent lectin domain capable of interacting with glycoconjugates present on microorganisms and leukocytes. Accordingly, we evaluated the extent and localization of SP-D in the lower respiratory tract during Pneumocystis pneumonia in an immunosuppressed rat model and examined its role in modulating interaction of P. carinii with macrophages. We report that SP-D is a major component of the alveolar exudates that typify P. carinii pneumonia and is present bound to the surface of P. carinii organisms in vivo. We further demonstrate that SP-D binds to P. carinii through saccharide-mediated interactions with gpA present on the surface of the organism. Lastly, we show that SP-D augments binding of P. carinii to alveolar macrophages, but does not significantly enhance macrophage phagocytosis of the organism. The interaction of SP-D with gpA represents an additional important component of the host-parasite relationship during P. carinii pneumonia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.