ArticleThe Journal of clinical investigation1995
Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 275 citations in OpenAlex.
- Melatonin attenuates inflammation, remodeling, and oxidative stress in experimental models of asthma and COPD.Frontiers in immunology · 2026Article
- IL-10Scientific reports · 2024Article
- Endogenous inhibitory mechanisms in asthma.The journal of allergy and clinical immunology. Global · 2023Review
- Interleukin-10-alveolar macrophage cell membrane-coated nanoparticles alleviate airway inflammation and regulate Th17/regulatory T cell balance in a mouse model.Frontiers in immunology · 2023Article
- Article
- CpG-ODN Signaling via Dendritic Cells-Expressing MyD88, but Not IL-10, Inhibits Allergic Sensitization.Vaccines · 2021Article
- Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responses.BMC medical genomics · 2016Article
- Enhanced inflammation in aged mice following infection with Streptococcus pneumoniae is associated with decreased IL-10 and augmented chemokine production.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- The role of macrophage IL-10/innate IFN interplay during virus-induced asthma.Reviews in medical virology · 2015Review
- T helper subsets in allergic eye disease.Current opinion in allergy and clinical immunology · 2014Review
- Exogenous interleukin-10 alleviates allergic inflammation but inhibits local interleukin-10 expression in a mouse allergic rhinitis model.BMC immunology · 2014Article
- The cell-to-cell coordination between activated T cells and CpG-stimulated macrophages synergistically induce elevated levels of IL-10 via NF-κB1, STAT3, and CD40/CD154.Cell communication and signaling : CCS · 2013Article
- Dual role of interleukin-10 in the regulation of respiratory syncitial virus (RSV)-induced lung inflammation.Clinical and experimental immunology · 2013Article
- Cellular and molecular mechanisms of TSLP function in human allergic disorders--TSLP programs the "Th2 code" in dendritic cells.Allergology international : official journal of the Japanese Society of Allergology · 2012Review
- Absence of Foxp3+ regulatory T cells during allergen provocation does not exacerbate murine allergic airway inflammation.PloS one · 2012Article
- Regulatory T cells and the control of the allergic response.Journal of allergy · 2012Article
- Inhibition of IL-10 production by maternal antibodies against Group B Streptococcus GAPDH confers immunity to offspring by favoring neutrophil recruitment.PLoS pathogens · 2011Article
- Cytokine gene-modulated dendritic cells protect against allergic airway inflammation by inducing IL-10(+)IFN-gamma(+)CD4(+) T cells.Gene therapy · 2010Article
- Effects of alpha 1-antitrypsin on endotoxin-induced lung inflammation in vivo.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Article
- Allergen-specific subcutaneous immunotherapy in allergic asthma: immunologic mechanisms and improvement.The Libyan journal of medicine · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This report examines the effect of recombinant murine (rm) IL-10 on antigen-induced cellular recruitment into the airways of sensitized Balb/c mice. The intranasal instillation of 10 micrograms ovalbumin induced an early (6-24 h) increase in the number of neutrophils, and a late rise (24-96 h) in that of eosinophils in the bronchoalveolar lavage (BAL) fluid and bronchial tissue. A single intranasal instillation of 0.01-0.1 microgram of rmIL-10, administered concurrently with ovalbumin, but not 1 or 3 h thereafter, dose-dependently inhibited both airway neutrophilia and eosinophilia. This phenomenon was suppressed by treating the sensitized mice with 1 mg/mouse of a neutralizing anti-IL-10 mAb, which increased significantly ovalbumin-induced neutrophil and eosinophil accumulation in the BAL fluid. These results suggest that antigen stimulation may trigger the in vivo generation of IL-10, which, in turn, participates in the leukocyte infiltration into the airways. rmIL-10 also reduced TNF-alpha release in the BAL fluid observed 1 and 3 h after antigen challenge. Furthermore, the intranasal instillation of an anti-TNF-alpha antiserum to sensitized mice markedly reduced ovalbumin-induced neutrophil and eosinophil accumulation in the BAL fluid. These findings indicate that leukocyte infiltration into the airways of antigen-challenged mice is regulated by IL-10. Furthermore, inhibition of TNF-alpha production by rmIL-10 suggests that allergic airway inflammation and TNF-alpha formation are parallel events in this model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.