ArticleInfection and immunity1995
Beta-1,2-linked oligomannosides from Candida albicans act as signals for tumor necrosis factor alpha production.
Article in Infection and immunity, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 99 citations in OpenAlex.
- Antibodies as Models and Tools to DecipherJournal of fungi (Basel, Switzerland) · 2023Review
- Importance ofFrontiers in cellular and infection microbiology · 2019Article
- Clinical Impact of Antifungal Susceptibility, Biofilm Formation and Mannoside Expression ofFrontiers in microbiology · 2018Article
- A Proposal of Remedies for Oral Diseases Caused by Candida: A Mini Review.Frontiers in microbiology · 2018Review
- β-1,2-Mannosyltransferases 1 and 3 Participate in Yeast and Hyphae O- and N-Linked Mannosylation and Alter Candida albicans Fitness During Infection.Open forum infectious diseases · 2015Article
- Candida albicans phospholipomannan: a sweet spot for controlling host response/inflammation.Seminars in immunopathology · 2015Review
- Discovery of two β-1,2-mannoside phosphorylases showing different chain-length specificities from Thermoanaerobacter sp. X-514.PloS one · 2014Article
- Deficient beta-mannosylation of Candida albicans phospholipomannan affects the proinflammatory response in macrophages.PloS one · 2013Article
- Evaluation of immunostimulatory activities of synthetic mannose-containing structures mimicking the β-(1->2)-linked cell wall mannans of Candida albicans.Clinical and vaccine immunology : CVI · 2012Article
- Chemical structure of the cell-wall mannan of Candida albicans serotype A and its difference in yeast and hyphal forms.The Biochemical journal · 2007Article
- Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors.The Journal of clinical investigation · 2006Article
- Increased levels of Candida albicans mannan-specific T-cell-derived antigen binding molecules in patients with invasive candidiasis.Clinical and vaccine immunology : CVI · 2006Article
- Surface glycans of Candida albicans and other pathogenic fungi: physiological roles, clinical uses, and experimental challenges.Clinical microbiology reviews · 2004Review
- Beta-1,2- and alpha-1,2-linked oligomannosides mediate adherence of Candida albicans blastospores to human enterocytes in vitro.Infection and immunity · 2003Article
- Seroreactivity against Saccharomyces cerevisiae in patients with Crohn's disease and celiac disease.World journal of gastroenterology · 2003Article
- Synthetic analogues of beta-1,2 oligomannosides prevent intestinal colonization by the pathogenic yeast Candida albicans.Antimicrobial agents and chemotherapy · 2002Article
- Beta-1,2-mannosylation of Candida albicans mannoproteins and glycolipids differs with growth temperature and serotype.Infection and immunity · 2002Article
- Contribution of phospholipomannan to the surface expression of beta-1,2-oligomannosides in Candida albicans and its presence in cell wall extracts.Infection and immunity · 2002Article
- Comparison of the hydrophobic properties of Candida albicans and Candida dubliniensis.Infection and immunity · 2001Article
- beta-1,2-linked oligomannosides from Candida albicans bind to a 32-kilodalton macrophage membrane protein homologous to the mammalian lectin galectin-3.Infection and immunity · 2000Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Different cell wall components from Candida albicans have been shown to stimulate murine macrophages for tumor necrosis factor alpha (TNF-alpha) secretion. All of these molecules contain beta-1,2-oligomannosides. In order to examine their role in TNF-alpha production, acid-labile oligosaccharides, released from C. albicans VW32 cell wall phosphopeptidomannan by mild acid hydrolysis, and previously shown to correspond to homopolymers of beta-1,2-linked mannopyranosyl units, were separated by gel filtration chromatography according to their degree of polymerization. Murine macrophages incubated with purified oligomannosides (M2 to M8) released TNF-alpha to an extent which was dependent on, although not directly correlated with, the length of the mannosyl chain. Slight activity was observed with M4 and M5; M6 and M7 had virtually no effect, whereas M8 was associated with strong TNF-alpha release. This effect of M8 was dose dependent and was not altered by polymyxin B, known to interfere with lipopolysaccharide-induced TNF-alpha production. These results suggest that stimulation of TNF-alpha release by C. albicans glycoconjugates containing beta-1,2-linked oligomannosides may be due, at least in part, to the presence of these components.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.