ArticleInfection and immunity1995
Depressed T-cell proliferation associated with susceptibility to experimental Taenia crassiceps infection.
Article in Infection and immunity, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Endogenous innate sensor NLRP3 is a key component in peritoneal macrophage dynamics required for cestode establishment.Immunologic research · 2024Article
- Standardizing an Experimental Murine Model of Extraparenchymal Neurocysticercosis That Immunologically Resembles Human Infection.Brain sciences · 2023Article
- Differential Protein Expression ofPathogens (Basel, Switzerland) · 2023Article
- Regulatory T Cells as an Escape Mechanism to the Immune Response inFrontiers in cellular and infection microbiology · 2021Article
- EXPERIMENTAL SUBCUTANEOUS CYSTICERCOSIS BY Taenia crassiceps IN BALB/c AND C57BL/6 MICE.Revista do Instituto de Medicina Tropical de Sao Paulo · 2016Article
- Helminth induced suppression of macrophage activation is correlated with inhibition of calcium channel activity.PloS one · 2014Article
- Somatostatin negatively regulates parasite burden and granulomatous responses in cysticercosis.BioMed research international · 2014Article
- Immunoregulation by Taenia crassiceps and its antigens.BioMed research international · 2013Article
- Substance P causes seizures in neurocysticercosis.PLoS pathogens · 2012Article
- Identification of loci controlling restriction of parasite growth in experimental Taenia crassiceps cysticercosis.PLoS neglected tropical diseases · 2011Article
- Cestode antigens induce a tolerogenic-like phenotype and inhibit LPS inflammatory responses in human dendritic cells.International journal of biological sciences · 2011Article
- Decrease of peritoneal inflammatory CD4(+), CD8(+), CD19(+) lymphocytes and apoptosis of eosinophils in a murine Taenia crassiceps infection.Parasitology research · 2010Article
- Substance P signaling contributes to granuloma formation in Taenia crassiceps infection, a murine model of cysticercosis.Journal of biomedicine & biotechnology · 2010Article
- Absence of the SP/SP receptor circuitry in the substance P-precursor knockout mice or SP receptor, neurokinin (NK)1 knockout mice leads to an inhibited cytokine response in granulomas associated with murine Taenia crassiceps infection.The Journal of parasitology · 2008Article
- Carbohydrate components of Taenia crassiceps metacestodes display Th2-adjuvant and anti-inflammatory properties when co-injected with bystander antigen.Parasitology research · 2006Article
- A STAT4-dependent Th1 response is required for resistance to the helminth parasite Taenia crassiceps.Infection and immunity · 2004Article
- CD4+ and CD19+ splenocytes undergo apoptosis during an experimental murine infection with Taenia crassiceps.Parasitology research · 2003Article
- Taenia crassiceps cysticercosis: immune response in susceptible and resistant BALB/c mouse substrains.Parasitology research · 2003Article
- Sequential expression of the neuropeptides substance P and somatostatin in granulomas associated with murine cysticercosis.Infection and immunity · 2002Article
- Antigen-specific suppression of cultured lymphocytes from patients with neurocysticercosis.Clinical and experimental immunology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peritoneal infection with Taenia crassiceps cysticerci of naturally resistant (C57BL/10J and C57BL/6J) and susceptible (BALB/cAnN) mice induces a cellular immune depression. T-cell proliferation in response to concanavalin A (ConA) or anti-CD3 was significantly depressed in infected mice of all strains tested. However, in resistant mice, the diminished response to ConA was transient and animals recovered normal responsiveness at day 40, whereas susceptible mice remained suppressed throughout the 40 days of the experiment. In contrast, the proliferative response to anti-CD3 was lower in infected mice than in noninfected controls regardless of differences in natural susceptibility of the strains. Intraperitoneal injection of mice with a parasite extract also induced a depression of the response to ConA, although not as strong as that produced by the parasite itself. This depression is not due to direct effects by parasite antigens over host lymphocytes, as proliferation is not affected by the presence of cysticercal antigens added in vitro. Diminished interleukin-2 production during the parasitosis accounts at least in part for the diminished responses to ConA. A primary infection favors parasite establishment after a second challenge, pointing to the relevance of the immunodepression in generating a host environment favorable to the parasite.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.