ArticleGenetics1995
Multiple elements and auto-repression regulate Rox1, a repressor of hypoxic genes in Saccharomyces cerevisiae.
Article in Genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 99 citations in OpenAlex.
- A toolkit for facilitating markerless integration of expression cassettes in Komagataella phaffii via CRISPR/Cas9.Microbial cell factories · 2025Article
- Increased heme synthesis in yeast induces a metabolic switch from fermentation to respiration even under conditions of glucose repression.The Journal of biological chemistry · 2017Article
- Article
- Repression of the Low Affinity Iron Transporter Gene FET4: A NOVEL MECHANISM AGAINST CADMIUM TOXICITY ORCHESTRATED BY YAP1 VIA ROX1.The Journal of biological chemistry · 2015Article
- Redox and reactive oxygen species regulation of mitochondrial cytochrome C oxidase biogenesis.Antioxidants & redox signaling · 2013Review
- Negative feedback confers mutational robustness in yeast transcription factor regulation.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- The general transcriptional repressor Tup1 is required for dimorphism and virulence in a fungal plant pathogen.PLoS pathogens · 2011Article
- The effect of prior assumptions over the weights in BayesPI with application to study protein-DNA interactions from ChIP-based high-throughput data.BMC bioinformatics · 2010Article
- Mechanism of de novo branched-chain amino acid synthesis as an alternative electron sink in hypoxic Aspergillus nidulans cells.Applied and environmental microbiology · 2010Article
- Regulation of hypoxia adaptation: an overlooked virulence attribute of pathogenic fungi?Medical mycology · 2010Review
- BayesPI - a new model to study protein-DNA interactions: a case study of condition-specific protein binding parameters for Yeast transcription factors.BMC bioinformatics · 2009Article
- Suppression mechanisms of COX assembly defects in yeast and human: insights into the COX assembly process.Biochimica et biophysica acta · 2009Review
- Inferring activity changes of transcription factors by binding association with sorted expression profiles.BMC bioinformatics · 2007Article
- Heme levels switch the function of Hap1 of Saccharomyces cerevisiae between transcriptional activator and transcriptional repressor.Molecular and cellular biology · 2007Article
- Roles of Candida albicans Sfl1 in hyphal development.Eukaryotic cell · 2007Article
- Transcriptional monitoring of steady state and effects of anaerobic phases in chemostat cultures of the filamentous fungus Trichoderma reesei.BMC genomics · 2006Article
- Synergy among differentially regulated repressors of the ribonucleotide diphosphate reductase genes of Saccharomyces cerevisiae.Eukaryotic cell · 2006Article
- An improved map of conserved regulatory sites for Saccharomyces cerevisiae.BMC bioinformatics · 2006Article
- Inferring transcriptional modules from ChIP-chip, motif and microarray data.Genome biology · 2006Article
- Combinatorial repression of the hypoxic genes of Saccharomyces cerevisiae by DNA binding proteins Rox1 and Mot3.Eukaryotic cell · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The ROX1 gene encodes a heme-induced repressor of hypoxic genes in yeast. Using RNA blot analysis and a ROX1/lacZ fusion construct that included the ROX1 upstream region and only the first codon, we discovered that Rox1 represses its own expression. Gel-retardation experiments indicated that Rox1 was capable of binding to its own upstream region. Overexpression of Rox1 from the inducible GAL1 promoter was found to be inhibitory to cell growth. Also, we found that, as reported previously, Hap1 is partially responsible for heme-induction of ROX1, but, in addition, it also may play a role in ROX1 repression in the absence of heme. There is a second repressor of anaerobic ROX1 expression that requires the general repressor Tup1/Ssn6 for its function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.