ArticleMammalian genome : official journal of the International Mammalian Genome Society1995
Transcripts from opposite strands of gamma satellite DNA are differentially expressed during mouse development.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 103 citations in OpenAlex.
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- AGO1 regulates pericentromeric regions in mouse embryonic stem cells.Life science alliance · 2022Article
- The Evolution of Widespread Recombination Suppression on the Dwarf Hamster (Phodopus) X Chromosome.Genome biology and evolution · 2022Article
- Molecular Dynamics and Evolution of Centromeres in the Genus Equus.International journal of molecular sciences · 2022Review
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- Phospho-Tau and Chromatin Landscapes in Early and Late Alzheimer's Disease.International journal of molecular sciences · 2021Review
- Centromeres Transcription and Transcripts for Better and for Worse.Progress in molecular and subcellular biology · 2021Article
- Satellite DNA-Mediated Gene Expression Regulation: Physiological and Evolutionary Implication.Progress in molecular and subcellular biology · 2021Article
- MIWI prevents aneuploidy during meiosis by cleaving excess satellite RNA.The EMBO journal · 2020Article
- DICER regulates the expression of major satellite repeat transcripts and meiotic chromosome segregation during spermatogenesis.Nucleic acids research · 2020Article
- Review
- Genetic and epigenetic effects on centromere establishment.Chromosoma · 2020Review
- Roles for Non-coding RNAs in Spatial Genome Organization.Frontiers in cell and developmental biology · 2019Review
- Cooperative Control of Ecdysone Biosynthesis inGenetics · 2018Article
- Centromere and Pericentromere Transcription: Roles and Regulation … in Sickness and in Health.Frontiers in genetics · 2018Review
- Silencing markers are retained on pericentric heterochromatin during murine primordial germ cell development.Epigenetics & chromatin · 2017Article
- SIRT6: a new guardian of mitosis.Nature structural & molecular biology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using in vitro immuno-selected retinoic acid response elements, we have isolated mouse genomic clones containing major (gamma) satellite DNA repeats that are considered as typical of chromosome centromeres. Several cDNA clones were then isolated from a F9 cell cDNA library and were found to harbor variants of the 234-base pair consensus gamma satellite monomer. In Northern analysis, these satellite DNA sequences hybridized predominantly to an approximately 1.8-kb RNA species in polyadenylated RNA from P19 cells. These transcripts were strongly repressed by retinoic acid, and nuclear run-on assays revealed that this repression was, at least in part, mediated at the transcriptional level. Satellite transcripts were also detected in HeLa cells, where they were similarly down-regulated by retinoids. Heterogeneously sized satellite transcripts were detected in RNA from specific mouse tissues, such as fetuses (but not placenta), adult liver, and testis. In situ hybridization analysis revealed that satellite transcripts are generated from opposite DNA strands and are differentially expressed in cells of the developing central nervous system as well as in adult liver and testis. These data may have implications on retinoic acid-mediated transcriptional regulation and centromere function.
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