ArticleMammalian genome : official journal of the International Mammalian Genome Society1995
The major locus for multifactorial nonsyndromic cleft lip maps to mouse chromosome 11.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 46 citations in OpenAlex.
- Role of carotenoids and retinoids during heart development.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2020Review
- A comprehensive review of the genetic basis of cleft lip and palate.Journal of oral and maxillofacial pathology : JOMFP · 2012Article
- Genetics of cleft lip and palate : a review.The Malaysian journal of medical sciences : MJMS · 2007Article
- Development of the upper lip: morphogenetic and molecular mechanisms.Developmental dynamics : an official publication of the American Association of Anatomists · 2006Review
- Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice.Developmental dynamics : an official publication of the American Association of Anatomists · 2006Article
- Analysis of polymorphic TGFB1 codons 10, 25, and 263 in a German patient group with non-syndromic cleft lip, alveolus, and palate compared with healthy adults.BMC medical genetics · 2004Article
- The cleft lip and palate defects in Dancer mutant mice result from gain of function of the Tbx10 gene.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Genome scan for teratogen-induced clefting susceptibility loci in the mouse: evidence of both allelic and locus heterogeneity distinguishing cleft lip and cleft palate.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- The clf1 gene maps to a 2- to 3-cM region of distal mouse chromosome 11.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- The lidgap-Gates (lgGa) mutation for open eyelids at birth maps to mouse chromosome 13.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- Evidence for an association between nonsyndromic cleft lip with or without cleft palate and a gene located on the long arm of chromosome 4.American journal of human genetics · 1995Article
- Face facts: genes, environment, and clefts.American journal of human genetics · 1995Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cleft lip with or without cleft palate, CL(P), a common human birth defect, has a genetically complex etiology. An animal model with a similarly complex genetic basis is established in the A/WySn mouse strain, in which 20% of newborns have CL(P). Using a newly created congenic strain, AEJ.A, and SSLP markers, we have mapped a major CL(P)-causing gene derived from the A/WySn strain. This locus, here named clf1 (cleft lip) maps to Chromosome (Chr) 11 to a region having linkage homology with human 17q21-24, supporting reports of association of human CL(P) with the retinoic acid receptor alpha (RARA) locus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.