ArticleCurrent microbiology1994
Identification and characterization of Mycobacterium paratuberculosis recombinant proteins expressed in E. coli.
Article in Current microbiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 35 citations in OpenAlex.
- Expression cloning of gamma interferon-inducing antigens of Mycobacterium avium subsp. paratuberculosis.Infection and immunity · 2005Article
- Characterization of novel coding sequences specific to Mycobacterium avium subsp. paratuberculosis: implications for diagnosis of Johne's Disease.Journal of clinical microbiology · 2004Article
- Expression and immunogenicity of proteins encoded by sequences specific to Mycobacterium avium subsp. paratuberculosis.Journal of clinical microbiology · 2004Article
- Seroreactivities against Saccharomyces cerevisiae and Mycobacterium avium subsp. paratuberculosis p35 and p36 antigens in Crohn's disease patients.Digestive diseases and sciences · 2002Article
- Mycobacterium avium subsp. paratuberculosis in Veterinary Medicine.Clinical microbiology reviews · 2001Review
- A M(r) 34,000 proinflammatory outer membrane protein (oipA) of Helicobacter pylori.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Mycobacterium avium subsp. paratuberculosis in Crohn's disease is serologically positive.Clinical and diagnostic laboratory immunology · 1999Article
- Characterization of a specific Mycobacterium paratuberculosis recombinant clone expressing 35,000-molecular-weight antigen and reactivity with sera from animals with clinical and subclinical Johne's disease.Journal of clinical microbiology · 1997Article
- Identification of Mycobacterium avium complex in sarcoidosis.Journal of clinical microbiology · 1996Article
- Nucleotide sequence analysis and seroreactivities of the 65K heat shock protein from Mycobacterium paratuberculosis.Clinical and diagnostic laboratory immunology · 1995Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycobacterium paratuberculosis is the causative agent of Johne's disease, a chronic enteritis in ruminants, and it has also been isolated and identified from patients with Crohn's disease, an inflammatory bowel disease. The control of Johne's disease has been hampered by the lack of a reliable diagnostic test because of the large degree of antigenic cross-reactivity between mycobacterial and non-mycobacterial species. To help identify specific antigen(s) or epitope(s), an M. paratuberculosis expression library was screened with antibodies and DNA probes. In total, 54 clones were randomly picked, purified, and characterized by DNA probes and monoclonal antibodies with known specificity to individual mycobacterial antigens. Four clones carrying the heat shock protein 65K-, two representing the secreted protein 32K-, three representing the 21K-, and 20 clones representing the specific insertion element of M. paratuberculosis (IS900)-encoding genes and their gene products were identified and characterized. Well-defined recombinant antigens and/or epitopes representing M. paratuberculosis may facilitate the development of specific diagnostic tests and the investigation of their role in these chronic diseases.
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