ArticleCytotechnology1993
The effects of doxorubicin on embryonic spinal motoneurons cultured in vitro: cytoskeletal response.
Article in Cytotechnology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 4 citations in OpenAlex.
- N-acetylcysteine potentiates doxorubicin-induced ATM and p53 activation in ovarian cancer cells.International journal of oncology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interaction of doxorubicin with tubulin in spinal motoneuronal cells cultured in vitro has been examined by laser scan microscopy with an immunocytological double staining technique, and by biochemical analysis. Results obtained by laser scan microscopy indicate that doxorubicin (2 x 10(-8) M) was able to induce fragmentation or disappearance of microtubules in motoneuronal cells. Motoneurons were identified by their positivity to anti-CAT antibody. This observation was then studied by biochemical analysis on purified calf brain tubulin. Even treatment with a high dose of doxorubicin (1.2 x 10(-5) M) does not impair tubulin polymerization. The finding supports the possibility that doxorubicin interacts with MAPs or other polypeptides present in the cytomatrix that coassemble with tubulin and are necessary for microtubule formation.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.