Trial reportArchives of disease in childhood1995
Effect of continuous treatment with topical corticosteroid on episodic viral wheeze in preschool children.
Trial report in Archives of disease in childhood, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 166 citations in OpenAlex.
- Pharmacotherapy--treatment of intermittent asthma with ICSs.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2005Guideline
- Budesonide for chronic asthma in children and adults.The Cochrane database of systematic reviews · 2001Pooled it
- Beclomethasone for asthma in children: effects on linear growth.The Cochrane database of systematic reviews · 2000Pooled it
- Inhaled steroids for episodic viral wheeze of childhood.The Cochrane database of systematic reviews · 2000Pooled it
- Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing.The Journal of allergy and clinical immunology · 2008Trial
- Episodic viral wheeze in preschool children: effect of topical nasal corticosteroid prophylaxis.Thorax · 2003Trial
- Persistent wheezing in infants with an atopic tendency responds to inhaled fluticasone.Archives of disease in childhood · 2001Trial
- Structured discharge procedure for children admitted to hospital with acute asthma: a randomised controlled trial of nursing practice.Archives of disease in childhood · 1999Trial
- Review
- Time to Say Goodbye to Bronchiolitis, Viral Wheeze, Reactive Airways Disease, Wheeze Bronchitis and All That.Frontiers in pediatrics · 2020Review
- Emerging Therapies in the Treatment of Early Childhood Wheeze.Pediatric allergy, immunology, and pulmonology · 2019Article
- Matched cohort study of therapeutic strategies to prevent preschool wheezing/asthma attacks.Journal of asthma and allergy · 2018Article
- Treatment of asthma in young children: evidence-based recommendations.Asthma research and practice · 2016Review
- The evaluation of risk factors for recurrent hospitalizations resulting from wheezing attacks in preschool children.Italian journal of pediatrics · 2015Article
- Virus-induced modulation of lower airway diseases: pathogenesis and pharmacologic approaches to treatment.Pharmacology & therapeutics · 2015Review
- Treatment of Severe Acute Asthma is Damage Control.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2013Article
- Childhood asthma: diagnosis and treatment.Scientifica · 2012Review
- Steroid responsiveness and wheezing phenotypes.Paediatric respiratory reviews · 2011Review
- Inhaled corticosteroids in childhood asthma: the story continues.European journal of pediatrics · 2011Review
- The management of pre-school wheeze.Paediatric respiratory reviews · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute episodic wheeze related to viral infections is a common and distressing condition and treatment remains unsatisfactory. Although some benefit from the continuous use of inhaled steroids has been demonstrated in young wheezy children, their effect primarily on acute episodes has not been considered. In this study the effect of budesonide (400 micrograms/day) was assessed in a four month double blind parallel trial, in 41 children (0.7-6.0 years) with predominantly episodic viral wheeze. Analysis of the last three months showed no difference between budesonide or placebo in mean daily total symptom score (median values 0.6 and 0.63), episode number (mean values 2.6 and 2.4), or score/episode (mean value 30 and 31). Four months of treatment with inhaled budesonide had no effect on acute episodes of wheeze in this group of children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.