ArticleAmerican journal of human genetics1995
Proportion of genome shared identical by descent by relatives: concept, computation, and applications.
Article in American journal of human genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Article
- Two-locus identity coefficients in pedigrees.G3 (Bethesda, Md.) · 2023Article
- Causal inference for the covariance between breeding values under identity disequilibrium.Genetics, selection, evolution : GSE · 2022Article
- A phylogenetic approach for weighting genetic sequences.BMC bioinformatics · 2021Article
- Genome-wide non-HLA donor-recipient genetic differences influence renal allograft survival via early allograft fibrosis.Kidney international · 2020Article
- Article
- Meiotic recombination shapes precision of pedigree- and marker-based estimates of inbreeding.Heredity · 2017Article
- On estimation of genetic variance within families using genome-wide identity-by-descent sharing.Genetics, selection, evolution : GSE · 2013Article
- Review
- Estimation and partition of heritability in human populations using whole-genome analysis methods.Annual review of genetics · 2013Review
- Variation in actual relationship among descendants of inbred individuals.Genetics research · 2012Article
- A novel genome-information content-based statistic for genome-wide association analysis designed for next-generation sequencing data.Journal of computational biology : a journal of computational molecular cell biology · 2012Article
- Identification of Mendelian inconsistencies between SNP and pedigree information of sibs.Genetics, selection, evolution : GSE · 2011Article
- Variation in actual relationship as a consequence of Mendelian sampling and linkage.Genetics research · 2011Article
- Whole genome approaches to quantitative genetics.Genetica · 2009Review
- Prediction of multilocus identity-by-descent.Genetics · 2007Article
- Assumption-free estimation of heritability from genome-wide identity-by-descent sharing between full siblings.PLoS genetics · 2006Article
- Distribution of genome shared identical by descent by two individuals in grandparent-type relationship.Genetics · 2000Article
- Selection with recurrent backcrossing to develop congenic lines for quantitative trait loci analysis.Genetics · 1998Article
- Genome scanning for segments shared identical by descent among distant relatives in isolated populations.American journal of human genetics · 1997Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
One widely used measure of genetic similarity for pairs of relatives is gene identity-by-descent (IBD) sharing. Genes that are copies of a single gene in a common ancestor of the individuals who now carry them are said to be IBD. One obvious extension of the IBD concept is IBD gene(s) shared by more than two individuals. In this paper, I further extend the gene IBD concept to the proportion of genomes shared IBD by every member of a group of relatives. Genome may refer either to the entire autosomal genome or to one or more chromosomal segments or regions with known lengths. Consideration of a genome instead of one or two loci has several advantages. I present a model to describe the crossover process, based on the work of K. P. Donnelly. On the basis of this model, I give a mathematical definition of the proportion of genome shared IBD by relatives, or IBDP for short. Since the distribution of the IBDP is in general very difficult to determine, and since in most applications the mean and variance of the IBDP will suffice, I then provide a method for computing the first two moments of the IBDP. Applications to assessing gene survival, to genetic resemblance between two relatives, and to gene mapping are illustrated with examples. Finally, I discuss the utility of the IBDP in other areas.
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7762570PMC1801111What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.