ArticleAmerican journal of human genetics1995
Molecular mapping of a recombination hotspot located in the second intron of the human TAP2 locus.
Article in American journal of human genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis.PLoS genetics · 2012Pooled it
- Revisit of Optimal Donor Number Estimation in the Hong Kong Bone Marrow Donor Registry.Frontiers in immunology · 2021Article
- Evolutionary basis of HLA-DPB1 alleles affects acute GVHD in unrelated donor stem cell transplantation.Blood · 2018Article
- HLA-DP in unrelated hematopoietic cell transplantation revisited: challenges and opportunities.Blood · 2017Review
- Meiotic recombinations within major histocompatibility complex of human embryos.Immunogenetics · 2012Article
- Article
- The human Major Histocompatibility Complex as a paradigm in genomics research.Briefings in functional genomics & proteomics · 2009Review
- MHC loci affecting cervical cancer risk: distinguishing the effects of HLA-DQB1 and non-HLA genes TNF, LTA, TAP1 and TAP2.Genes and immunity · 2008Article
- Cis- and trans-acting elements regulate the mouse Psmb9 meiotic recombination hotspot.PLoS genetics · 2007Article
- Article
- Immunogenomics: molecular hide and seek.Human genomics · 2006Review
- A high-resolution linkage-disequilibrium map of the human major histocompatibility complex and first generation of tag single-nucleotide polymorphisms.American journal of human genetics · 2005Article
- Population genetics of CAPN10 and GPR35: implications for the evolution of type 2 diabetes variants.American journal of human genetics · 2005Article
- HLA-DRB1, TAP2/TAP1, and HLA-DPB1 haplotypes in Finnish juvenile idiopathic arthritis: more complexity within the MHC.Genes and immunity · 2004Article
- Uncommon deletions of the Smith-Magenis syndrome region can be recurrent when alternate low-copy repeats act as homologous recombination substrates.American journal of human genetics · 2004Article
- Alleles of the hotspot cog are codominant in effect on recombination in the his-3 region of Neurospora.Genetics · 2004Article
- Meiotic recombination hot spots and human DNA diversity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2004Review
- High-resolution patterns of meiotic recombination across the human major histocompatibility complex.American journal of human genetics · 2002Article
- Molecular studies and NK cell function of a new case of TAP2 homozygous human deficiency.Clinical and experimental immunology · 2001Article
- Characterization of recombination in the HLA class II region.American journal of human genetics · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Recombination across the HLA class II region is not randomly distributed, as indicated by both strong linkage disequilibrium within the 100 kb encompassing the DRB1-DQA1-DQB1 loci and complete equilibrium between TAP1 and TAP2, the closest variant sites of which are < 15 kb. In an attempt to explain these observations, 39 novel polymorphic markers in a region encompassing the TAP, LMP, and DOB genes were used to delineate the site of crossover in 11 class II recombinant chromosomes. SSCP demonstrated that two recombination events occurred within an 850-bp interval in the second intron of TAP2, which separates the variant sites of TAP1 and TAP2. These data indicate the presence of a recombination hotspot, the first to be identified from the analysis of familial transmission in the human major histocompatibility complex. The region of crossover was cloned and sequenced from one of the recombinants, further defining the crossover site to a 138-bp segment nested within the 850-bp region. This represents the most precisely defined region of recombination in the human genome.
Indexed as
Identifiers
7762558PMC1801095What OpenQuestion holds
Registered trials
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